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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation 期刊论文

编号：

2d671e06-2a51-4e79-aef7-367737af25a2
作者：

Jin, Lingtao^[1];Chun, Jaemoo^[1];Pan, Chaoyun^[1];Li, Dan^[1];Lin, Ruiting^[1];Alesi, Gina N.^[1];Wang, Xu^[1];Kang, HeeBum^[1];Song, Lina^[2];Wang, Dongsheng^[1];Zhang, Guojing^[1];Fan, Jun^[3];Boggon, Titus J.^[4];Zhou, Lu(周璐)^[5]Kowalski, Jeanne^[6];Qu, ChengKui^[1,7];Steuer, Conor E.^[1];Chen, Georgia Z.^[1];Saba, Nabil F.^[1];Boise, Lawrence H.^[1];Owonikoko, Taofeek K.^[1];Khuri, Fadlo R.^[1];Magliocca, Kelly R.^[8];Shin, Dong M.^[1];Lonial, Sagar^[1];Kang, Sumin^[1];
语种：

English
期刊：

CANCER CELL ISSN：1535-6108 2018 年 34 卷 2 期 (315 - +) ; AUG 13
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摘要：

Platinum-based chemotherapeutics represent a mainstay of cancer therapy, but resistance limits their curative potential. Through a kinome RNAi screen, we identified microtubule-associated serine/threonine kinase 1 (MAST1) as a main driver of cisplatin resistance in human cancers. Mechanistically, cisplatin but no other DNA-damaging agents inhibit the MAPK pathway by dissociating cRaf from MEK1, while MAST1 replaces cRaf to reactivate the MAPK pathway in a cRaf-independent manner. We show clinical evidence that expression of MAST1, both initial and cisplatin-induced, contributes to platinum resistance and worse clinical outcome. Targeting MAST1 with lestaurtinib, a recently identified MAST1 inhibitor, restores cisplatin sensitivity, leading to the synergistic attenuation of cancer cell proliferation and tumor growth in human cancer cells and patient-derived xenograft models.
推荐引用方式
GB/T 7714：

Jin Lingtao,Chun Jaemoo,Pan Chaoyun, et al. MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation [J].CANCER CELL,2018,34(2):315-+.
APA：

Jin Lingtao,Chun Jaemoo,Pan Chaoyun,Li Dan,&Kang Sumin.(2018).MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation .CANCER CELL,34(2):315-+.
MLA：

Jin Lingtao, et al. "MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation" .CANCER CELL 34,2(2018):315-+.
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