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Systemic inflammatory responses predict survival outcomes and male gender predicts metachronous bladder cancer of upper tract urothelial carcinoma 期刊论文

编号：

2d98b429-d048-4036-8fd3-3c8c1e2b6e54
作者：

Jiang, Guangliang^[1];Wang, Hui^[1];Wang, Lujia(王路加)*^[1]Zhou, Zhongwen(周仲文)^[2]Ding, Qiang(丁强)^[1]Xu, Ke(徐可)*^[1]
语种：

English
期刊：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE ISSN：1940-5901 2017 年 10 卷 5 期 (8094 - 8101)
收录：
关键词：

Upper tract urothelial carcinoma male gender systemic inflammatory responses creatinine survival intravesical recurrence
摘要：

Objective: To investigate predictive markers for prognosis and intravesical recurrence in patients with upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). Material and methods: We retrospectively studied 113 patients with UTUCs who underwent RNU between December 2005 and January 2015 at Huashan Hospital and analyzed their clinicopathological parameters. Results: The median follow-up was 29 months (range 2-113 months). Until October 2015, 82 patients (72.6%) were still alive and intravesical recurrence was observed in 22 patients (20%) at the last follow-up. Multivariate analysis showed that tumor stage, tumor size, lymphovascular invasion (LVI), derived neutrophil-lymphocyte ratio (dNLR), serum creatinine and serum albumin were independent predictors for cancer-specific survival. Gender and prophylactic intravesical chemotherapy were independently associated with intravesical recurrence-free survival. Conclusion: Systemic inflammatory responses, including blood dNLR and serum albumin, were potential prognostic factors for UTUC patients after RNU, which suggested that inflammatory response mechanisms played an important role in prognosis of patients with UTUC. Besides intravesical chemotherapy, male gender was an independent risk factor for metachronous bladder cancer for UTUC patients underwent RNU.
推荐引用方式
GB/T 7714：

Jiang Guangliang,Wang Hui,Wang Lujia, et al. Systemic inflammatory responses predict survival outcomes and male gender predicts metachronous bladder cancer of upper tract urothelial carcinoma [J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2017,10(5):8094-8101.
APA：

Jiang Guangliang,Wang Hui,Wang Lujia,Zhou Zhongwen,&Xu Ke.(2017).Systemic inflammatory responses predict survival outcomes and male gender predicts metachronous bladder cancer of upper tract urothelial carcinoma .INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,10(5):8094-8101.
MLA：

Jiang Guangliang, et al. "Systemic inflammatory responses predict survival outcomes and male gender predicts metachronous bladder cancer of upper tract urothelial carcinoma" .INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 10,5(2017):8094-8101.

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