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Dual antiplatelet therapy may increase the risk of non-intracranial haemorrhage in patients with minor strokes: a subgroup analysis of the CHANCE trial. 期刊论文

编号：

31a67d19-44c2-4210-97f0-38ec5b0d815f
作者：

Wang David^[1];Gui Li^[2];Dong Yi(董漪)^[3]Li Hao^[4];Li Shujuan^[5];Zheng Huaguang^[6];Wang Anxin^[7];Meng Xia^[7];Liu LiPing^[8];Wang YiLong^[7];Wang Guangyao^[7];Jing Jing^[8];Li Zixiao^[7];Zhao XingQuan^[7];Wang YongJun^[9];
地址：

[1]Illinois Neurological Institute Stroke Network, Sisters of the Third Order of St. Francis Healthcare System, University of Illinois College of Medicine, Peoria, Illinois, USA.
[2]Southwest Hospital Stroke Center, Third Military University of Medical Sciences, Chongqing, China.
[3]Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
[4]China National Clinical Research Center for Neurological Diseases, Beijing, China.
[5]Chaoyang Hospital Neurology Department, Capital Medical University, Beijing, China.
[6]Department of Neurology, Beijing Tiantan Hospital, Tiantan Clinical Trial and Research Center for Stroke, Capital Medical University, Beijing, China.
[7]China National Clinical Research Center for Neurological Diseases, Beijing, China.;Department of Neurology, Beijing Tiantan Hospital, Tiantan Clinical Trial and Research Center for Stroke, Capital Medical University, Beijing, China.
[8]Department of Neurology, Beijing Tiantan Hospital, Tiantan Clinical Trial and Research Center for Stroke, Capital Medical University, Beijing, China.;Neurological Intensive Care Unit, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
[9]China National Clinical Research Center for Neurological Diseases, Beijing, China.;Department of Neurology, Beijing Tiantan Hospital, Tiantan Clinical Trial and Research Center for Stroke, Capital Medical University, Beijing, China.;Department of Neurology, Beijing Tiantan Hospital, Vascular Neurology,Capital Medical University, Beijing, China.
语种：

英文
期刊：

Stroke and vascular neurology ISSN：2059-8696 2016 年 1 卷 2 期 (29 - 36) ; 2016-Jun-
收录：
关键词：

Hemorrhage TIA dual antiplatelet minor stroke stroke prevention
摘要：

The aim of this study was to explore the difference between haemorrhagic events among those patients on either aspirin or aspirin plus clopidogrel who were enrolled in the Clopidogrel in High-Risk Patients with Acute Non-disabling Ischemic Cerebrovascular Events (CHANCE) trial.;This was an ad hoc analysis of the CHANCE trial; data on all patients with any haemorrhagic event were reviewed and analysed. Cox proportional hazards regression was used to determine factors association with any bleeding.;In the CHANCE trial, there were a total of 101 (2%) haemorrhagic events reported from 50 different hospitals. The clopidogrel-aspirin group had 60 (2.3%) cases and the aspirin group had 41 (1.6%, p=0.09). Moderate or severe haemorrhagic events occurred in 7 patients (0.3%) in the clopidogrel-aspirin group and in 8 (0.3%) in the aspirin group (p=0.73). Of 36 (0.7%) cases of intracranial haemorrhages, 20 (0.4%) were in the clopidogrel-aspirin group and 16 (0.3%) in the aspirin group. Each group had 8 (0.3%) cases of symptomatic haemorrhagic strokes. Other common haemorrhagic events included 24 (0.5%) cases of skin bruises, 13 (0.3%) gastrointestinal haemorrhages, 9 (0.2%) gum haemorrhages and 8 (0.2%) intraocular haemorrhages.;There was no overall significant difference in haemorrhagic events (p=0.29), especially in the rate of intracranial haemorrhages between the 2 treatment groups. However, patients enrolled with minor strokes had an increased risk of haemorrhagic events regardless of treatment group, not seen in patients with high-risk transient ischaemic attacks. Being elderly, of male gender and with a history of aspirin or proton pump inhibitor usage were associated with increased risk of haemorrhage. Patients with higher body mass index had lower risk of haemorrhagic events.;NCT00979589.;
推荐引用方式
GB/T 7714：

Wang David,Gui Li,Dong Yi, et al. Dual antiplatelet therapy may increase the risk of non-intracranial haemorrhage in patients with minor strokes: a subgroup analysis of the CHANCE trial. [J].Stroke and vascular neurology,2016,1(2):29-36.
APA：

Wang David,Gui Li,Dong Yi,Li Hao,&Wang Yong-Jun.(2016).Dual antiplatelet therapy may increase the risk of non-intracranial haemorrhage in patients with minor strokes: a subgroup analysis of the CHANCE trial. .Stroke and vascular neurology,1(2):29-36.
MLA：

Wang David, et al. "Dual antiplatelet therapy may increase the risk of non-intracranial haemorrhage in patients with minor strokes: a subgroup analysis of the CHANCE trial." .Stroke and vascular neurology 1,2(2016):29-36.

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