首页 / 院系成果 / 成果详情页

CD47 blockade reduces ischemia/reperfusion injury in donation after cardiac death rat kidney transplantation 期刊论文

编号：

31adae5e-1147-489c-96d0-aa1c91f1ac6a
作者：

Wang, Xuanchuan(王宣传)^[1,2]Xu, Min^[1];Jia, Jianluo^[1];Zhang, Zhengyan^[1];Gaut, Joseph P.^[3];Upadhya, Gundumi A.^[1];Manning, Pamela T.^[4];Lin, Yiing^[1];Chapman, William C.^[1];
语种：

English
期刊：

AMERICAN JOURNAL OF TRANSPLANTATION ISSN：1600-6135 2018 年 18 卷 4 期 (843 - 854) ; APR
收录：
关键词：

basic (laboratory) research science donation after circulatory death (DCD) donors and donation ischemia reperfusion injury (IRI) kidney transplantation nephrology
摘要：

Modulation of nitric oxide activity through blockade of CD47 signaling has been shown to reduce ischemia-reperfusion injury (IRI) in various models of tissue ischemia. Here, we evaluate the potential effect of an antibody-mediated CD47 blockade in a syngeneic and an allogeneic DCD rat kidney transplant model. The donor organ was subjected to 1hour of warm ischemia time after circulatory cessation, then flushed with a CD47 monoclonal antibody (CD47mAb) in the treatment group, or an isotype-matched immunoglobulin in the control group. We found that CD47mAb treatment improved survival rates in both models. Serum markers of renal injury were significantly decreased in the CD47mAb-treated group compared with the control group. Histologically the CD47mAb-treated group had significantly reduced scores of acute tubular injury and acute tubular necrosis. The expression of biomarkers related to mitochondrial stress and apoptosis also were significantly lower in the CD47mAb-treated groups. Overall, the protective effects of CD47 blockade were greater in the syngeneic model. Our data show that CD47mAb blockade decreased the IRI of DCD kidneys in rat transplant models. This therapy has the potential to improve DCD kidney transplant outcomes in the human setting. Antibody-mediated CD47 blockade in a rat kidney transplant model of donation after cardiac death improves recipient survival and graft function, and decreases inflammation, oxidative stress, and apoptosis. Xu et al's companion article is on .
推荐引用方式
GB/T 7714：

Wang Xuanchuan,Xu Min,Jia Jianluo, et al. CD47 blockade reduces ischemia/reperfusion injury in donation after cardiac death rat kidney transplantation [J].AMERICAN JOURNAL OF TRANSPLANTATION,2018,18(4):843-854.
APA：

Wang Xuanchuan,Xu Min,Jia Jianluo,Zhang Zhengyan,&Chapman William C..(2018).CD47 blockade reduces ischemia/reperfusion injury in donation after cardiac death rat kidney transplantation .AMERICAN JOURNAL OF TRANSPLANTATION,18(4):843-854.
MLA：

Wang Xuanchuan, et al. "CD47 blockade reduces ischemia/reperfusion injury in donation after cardiac death rat kidney transplantation" .AMERICAN JOURNAL OF TRANSPLANTATION 18,4(2018):843-854.

浏览次数：5  下载次数：0

分享到：

浏览次数：5

下载次数：0

打印次数：0