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Comparison of particle beam therapy and stereotactic body radiotherapy for early stage non-small cell lung cancer: A systematic review and hypothesis-generating meta-analysis 期刊论文

编号：

338419df-274e-481b-9260-d212079ce40f
作者：

Chi, Alexander^[1];Chen, Haiquan(陈海泉)^[2]Wen, Sijin^[3];Yan, Haijuan^[3];Liao, Zhongxing^[4];
语种：

English
期刊：

RADIOTHERAPY AND ONCOLOGY ISSN：0167-8140 2017 年 123 卷 3 期 (346 - 354) ; JUN
收录：
关键词：

Lung cancer Early stage PBT SBRT Stereotactic Particle beam
摘要：

Purpose: To assess hypo-fractionated particle beam therapy (PBT)'s efficacy relative to that of photon stereotactic body radiotherapy (SBRT) for early stage (ES) non-small cell lung cancer (NSCLC). Methods: Eligible studies were identified through extensive searches of the PubMed, Medline, Google-scholar, and Cochrane library databases from 2000 to 2016. Original English publications of ES NSCLC were included. A meta-analysis was performed to compare the survival outcome, toxicity profile, and patterns of failure following each treatment. Results: 72 SBRT studies and 9 hypo-fractionated PBT studies (mostly single-arm) were included. PBT was associated with improved overall survival (OS; p = 0.005) and progression-free survival (PFS; p = 0.01) in the univariate meta-analysis. The OS benefit did not reach its statistical significance after inclusion of operability into the final multivariate meta-analysis (p = 0.11); while the 3-year local control (LC) still favored PBT (p = 0.03). Conclusion: Although hypo-fractionated PBT may lead to additional clinical benefit when compared with photon SBRT, no statistically significant survival benefit from PBT over SBRT was observed in the treatment of ES NSCLC in this hypothesis-generating meta-analysis after adjusting for potential confounding variables. (C) 2017 Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Chi Alexander,Chen Haiquan,Wen Sijin, et al. Comparison of particle beam therapy and stereotactic body radiotherapy for early stage non-small cell lung cancer: A systematic review and hypothesis-generating meta-analysis [J].RADIOTHERAPY AND ONCOLOGY,2017,123(3):346-354.
APA：

Chi Alexander,Chen Haiquan,Wen Sijin,Yan Haijuan,&Liao Zhongxing.(2017).Comparison of particle beam therapy and stereotactic body radiotherapy for early stage non-small cell lung cancer: A systematic review and hypothesis-generating meta-analysis .RADIOTHERAPY AND ONCOLOGY,123(3):346-354.
MLA：

Chi Alexander, et al. "Comparison of particle beam therapy and stereotactic body radiotherapy for early stage non-small cell lung cancer: A systematic review and hypothesis-generating meta-analysis" .RADIOTHERAPY AND ONCOLOGY 123,3(2017):346-354.

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