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Preoperative omental metastasis-related maximum standardized fluorine-18-fluorodeoxyglucose uptake value can predict chemosensitivity and recurrence in advanced high-grade serous ovarian cancer patients 期刊论文

编号：

33cfba75-2033-41db-ba78-d072ef85a2dc
作者：

Sun, Yuyun^[1,3,4,5,6];Liu, Shuai^[1,3,4,5,6];Feng, Zheng(冯征)^[2]Cheng, Jingyi(程竞仪)^[1,3,4,5,6]Lu, Linjun^[1,3,4,5,6];Wang, Mingwei(王明伟)^[1,3,4,5,6]Yuan, Huiyu(袁慧瑜)^[1,3,4,5,6]Xu, Junyan(徐俊彦)*^[1,3,4,5,6]Zhang, Yingjian(章英剑)^[1,3,4,5,6]
语种：

英文
期刊：

NUCLEAR MEDICINE COMMUNICATIONS ISSN：0143-3636 2018 年 39 卷 8 期 (761 - 767) ; AUG
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关键词：

advanced high-grade serous ovarian cancer chemosensitivity F-18-FDG PET CT omental metastasis-to-primary tumor ratio prognosis
摘要：

Objective The aim of this study was to explore the clinical and prognostic implication of preoperative fluorine-18-fluorodeoxyglucose uptake value of omental metastasis-related in advanced high-grade serous ovarian cancer patients (HGSC).
Patients and methods We retrospectively investigated HGSC patients with omental metastasis (International Federation of Gynecology and Obstetrics stage IIIB-IV) who underwent PET/CT before primary surgery in our hospital between January 2010 and January 2016. All patients were confirmed omental metastasis by postoperative pathology. None of these patients received neoadjuvant chemotherapy. PET/CT parameters, including maximum standardized uptake value of primary ovary tumor (SUVp), omental metastasis (SUVo), and omental metastasis-to-primary tumor (SUVo/p) were measured. The relationships between PET/CT parameters and clinical characteristics were analyzed by t-test. Kaplan-Meier methods and log-rank tests were used to analyze progression-free survival (PFS) in univariate analysis. For multivariate analysis, COX regression analysis was used to assess the prognostic predictive value of PET/CT-derived variables.
Results Totally 81 advanced HGSC patients with omental metastasis were enrolled in our study, and 49 (60.5%) patients experienced recurrence and disease progression. The median (range) follow-up time was 18.5 (7-72) months. Older patients showed higher level of SUVo/p (P=0.006). Chemosensitive patients had lower levels of SUVo (P=0.009) and SUVo/p (P<0.001) than those chemoresistant ones. In univariate analysis, patients with better PFS were associated with lower SUVo (P<0.001) and SUVo/p (P<0.001). Multivariate analysis found only SUVo/p was an independent factor for PFS (P=0.006).
Conclusion Preoperative SUVo/p measured by fluorine-18-fluorodeoxyglucose PET/CT appeared to be an independent predictive factor for recurrence in advanced HGSC patients. Chemosensitive patients had lower omentum-related SUV values than those chemoresistant ones.
推荐引用方式
GB/T 7714：

Sun Yuyun,Liu Shuai,Feng Zheng, et al. Preoperative omental metastasis-related maximum standardized fluorine-18-fluorodeoxyglucose uptake value can predict chemosensitivity and recurrence in advanced high-grade serous ovarian cancer patients [J].NUCLEAR MEDICINE COMMUNICATIONS,2018,39(8):761-767.
APA：

Sun Yuyun,Liu Shuai,Feng Zheng,Cheng Jingyi,&Zhang Yingjian.(2018).Preoperative omental metastasis-related maximum standardized fluorine-18-fluorodeoxyglucose uptake value can predict chemosensitivity and recurrence in advanced high-grade serous ovarian cancer patients .NUCLEAR MEDICINE COMMUNICATIONS,39(8):761-767.
MLA：

Sun Yuyun, et al. "Preoperative omental metastasis-related maximum standardized fluorine-18-fluorodeoxyglucose uptake value can predict chemosensitivity and recurrence in advanced high-grade serous ovarian cancer patients" .NUCLEAR MEDICINE COMMUNICATIONS 39,8(2018):761-767.
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