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Antimicrobial susceptibilities of aerobic and facultative gram-negative bacilli isolated from Chinese patients with urinary tract infections between 2010 and 2014 期刊论文

编号：

34097483-fa68-4bc4-9b8a-4f1ea1cc572e
作者：

Yang, Qiwen^[1];Zhang, Hui^[1];Wang, Yao^[1];Xu, Zhipeng^[1];Zhang, Ge^[1];Chen, Xinxin^[1];Xu, Yingchun^[1];Cao, Bin^[2];Kong, Haishen^[3];Ni, Yuxing^[4];Yu, Yunsong^[5];Sun, Ziyong^[6];Hu, Bijie(胡必杰)^[7]Huang, Wenxiang^[8];Wang, Yong^[9];Wu, Anhua^[10];Feng, Xianju^[11];Liao, Kang^[12];Luo, Yanping^[13];Hu, Zhidong^[14];Chu, Yunzhuo^[15];Lu, Juan^[16];Su, Jianrong^[17];Gui, Bingdong^[18];Duan, Qiong^[19];Zhang, Shufang^[20];Shao, Haifeng^[21];Badal, Robert E.^[22];
语种：

英文
期刊：

BMC INFECTIOUS DISEASES ISSN：1471-2334 2017 年 17 卷 ; MAR 6
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关键词：

Urinary tract infections Extended spectrum beta-lactamases (ESBLs) Carbapenems Antimicrobial resistance
摘要：

Background: The objective of this study was to investigate the distribution and susceptibility of aerobic and facultative Gram-negative bacilli isolated from Chinese patients with UTIs collected within 48 h (community acquired, CA) or after 48 h (hospital acquired, HA) of hospital admission.
Methods: From 2010 to 2014, the minimum inhibitory concentrations (MICs) of 12 antibiotics for 4,332 aerobic and facultative Gram-negative bacilli, sampled in 21 hospitals in 16 cities, were determined by the broth microdilution method.
Results: Enterobacteriaceae composed 88.5% of the total isolates, with Escherichia coli (E. coli) (63.2%) the most commonly isolated species, followed by Klebsiella pneumoniae (K. pneumoniae) (12.2%). Non-Enterobacteriaceae accounted for only 11.5% of all isolates and included mainly Pseudomonas aeruginosa (P. aeruginosa) (6.9%) and Acinetobacter baumannii (A. baumannii) (3.3%). Among the antimicrobial agents tested, the susceptibility rates of E. coli to the two carbapenems, ertapenem and imipenem as well as amikacin and piperacillin-tazobactam ranged from 92.5 to 98.7%. Against K. pneumonia, the most potent antibiotics were imipenem (92.6% susceptibility), amikacin (89.2% susceptibility) and ertapenem (87.9% susceptibility). Although non-Enterobacteriaceae did not show high susceptibilities to the 12 common antibiotics, amikacin exhibited the highest in vitro activity against P. aeruginosa over the 5-year study period, followed by piperacillintazobactam, imipenem, ceftazidime, cefepime, ciprofloxacin, and levofloxacin. The Extended Spectrum BetaLactamase (ESBL) rates decreased slowly during the 5 years in E. coli from 68.6% in 2010 to 59.1% in 2014, in K. pneumoniae from 59.7 to 49.2%, and in Proteus mirabilis (P. mirabilis) from 40.0 to 26.1%. However, the ESBL rates were different in 5 regions of China (Northeast, North, East, South and Middle-China).
Conclusion: E. coli and K. pneumonia were the major pathogens causing UTIs and carbapenems and amikacin retained the highest susceptibility rates over the 5-year study period, indicating that they are good drug choices for empirical therapies, particularly of CA UTIs in China.
推荐引用方式
GB/T 7714：

Yang Qiwen,Zhang Hui,Wang Yao, et al. Antimicrobial susceptibilities of aerobic and facultative gram-negative bacilli isolated from Chinese patients with urinary tract infections between 2010 and 2014 [J].BMC INFECTIOUS DISEASES,2017,17.
APA：

Yang Qiwen,Zhang Hui,Wang Yao,Xu Zhipeng,&Badal Robert E..(2017).Antimicrobial susceptibilities of aerobic and facultative gram-negative bacilli isolated from Chinese patients with urinary tract infections between 2010 and 2014 .BMC INFECTIOUS DISEASES,17.
MLA：

Yang Qiwen, et al. "Antimicrobial susceptibilities of aerobic and facultative gram-negative bacilli isolated from Chinese patients with urinary tract infections between 2010 and 2014" .BMC INFECTIOUS DISEASES 17(2017).
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