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Outcome of Patients with Colorectal Liver Metastasis: Analysis of 1,613 Consecutive Cases 期刊论文

编号：

35e1dd3d-32b4-498c-8b4f-d41b3dc4ffda
作者：

Zhu Dexiang^[1,2,3,4];Ren Li^[1,2,3,4];Wei Ye^[1,2,3,4];Wu Haifu^[1,2,3,4];Zhong Yunshi^[1,2,3,4];Ye Qinghai^[5];Zhai Shenyong^[1,2,3,4];Xu Bo^[1,2,3,4];Liang Li^[1,2,3,4];Pan Xiangou^[1,2,3,4];Li Haohao^[1,2,3,4];Ye Lechi^[1,2,3,4];Liu Tianshu(刘天舒)^[6]Fan Jia(樊嘉)^[5]Qin Xinyu^[1,2,3,4];Xu Jianmin^[1,2,3,4];
语种：

English
期刊：

ANNALS OF SURGICAL ONCOLOGY ISSN：1068-9265 2012 年 19 卷 9 期 (2860 - 2868) ; SEP
收录：
摘要：

This study was designed to evaluate the long-time outcome of patients with colorectal liver metastasis (CRLM) undergoing different types of therapy and identify prognosis factors. From 2000 to 2010, 1,613 consecutive patients with CRLM were identified. Clinicopathological and outcome data were collected and analyzed by univariate and multivariate analyses. Synchronous liver metastasis (SLM), female, grade III-IV, T4 and N positive of primary tumor, bilobar disease, number of liver metastases a parts per thousand yen4, size of largest liver metastases a parts per thousand yen5 cm, serum CEA level a parts per thousand yen5 ng/ml, and CA19-9 level a parts per thousand yen37 u/ml were the predictors of adverse outcome using univariate analysis. The median survival and 5-year survival rate for patients after resection of liver metastases was 49.8 months and 47%, better than that for those after other therapy. In addition, patients without treatment had the poorest survival. Sixty-four initially unresectable patients underwent surgery after conversion therapy with a median survival of 36.9 months and a 5-year survival of 30%. By multivariate analysis, SLM, poorly differentiated primary tumor, number of liver metastases a parts per thousand yen4, size of largest liver metastases a parts per thousand yen5 cm, and no surgical treatment of liver metastases were found to be independent predictors of poor survival. Patients with CRLM could get long-term survival benefit from different types of therapy, and resection of liver metastases was the optimal strategy. A predictive model using these above five factors may be of use in stratifying patients who may benefit from intensive surveillance and adjuvant therapy.
推荐引用方式
GB/T 7714：

Zhu Dexiang,Ren Li,Wei Ye, et al. Outcome of Patients with Colorectal Liver Metastasis: Analysis of 1,613 Consecutive Cases [J].ANNALS OF SURGICAL ONCOLOGY,2012,19(9):2860-2868.
APA：

Zhu Dexiang,Ren Li,Wei Ye,Wu Haifu,&Xu Jianmin.(2012).Outcome of Patients with Colorectal Liver Metastasis: Analysis of 1,613 Consecutive Cases .ANNALS OF SURGICAL ONCOLOGY,19(9):2860-2868.
MLA：

Zhu Dexiang, et al. "Outcome of Patients with Colorectal Liver Metastasis: Analysis of 1,613 Consecutive Cases" .ANNALS OF SURGICAL ONCOLOGY 19,9(2012):2860-2868.

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