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Embryonic Trophoblasts Induce Decidual Regulatory T Cell Differentiation and Maternal-Fetal Tolerance through Thymic Stromal Lymphopoietin Instructing Dendritic Cells 期刊论文

编号：

379a4c14-303b-4c12-8450-07ee53056056
作者：

Du, MeiRong^[1] Guo, PeiFen^[1,2] Piao, HaiLan^[1] Wang, SongCun^[1] Sun, Chan^[1] Jin, LiPing^[1] Tao, Yu^[1] Li, YanHong^[1] Zhang, Di^[1] Zhu, Rui^[1] Fu, Qiang^[1] Li, DaJin^[1]
语种：

English
期刊：

JOURNAL OF IMMUNOLOGY ISSN：0022-1767 2014 年 192 卷 4 期 (1502 - 1511) ; FEB 15
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摘要：

Physiological pregnancy requires the maternal immune system to recognize and tolerate embryonic Ags. Although multiple mechanisms have been proposed, it is not yet clear how the fetus evades the maternal immune system. In this article, we demonstrate that trophoblast-derived thymic stromal lymphopoietin (TSLP) instructs decidual CD11c(+) dendritic cells (dDCs) with increased costimulatory molecules; MHC class II; and Th2/3-type, but not Th1-type, cytokines. TSLP-activated dDCs induce proliferation and differentiation of decidual CD4(+) CD25(-) T cells into CD4(+) CD25(+) FOXP3(+) regulatory T cells (Tregs) through TGF-beta 1. TSLPactivated dDC-induced Tregs display immunosuppressive features and express Th2-type cytokines. In addition, decidual CD4(+) CD25(+) FOXP3(+) Tregs promote invasiveness and HLA-G expression of trophoblasts, resulting in preferential production of Th2 cytokines and reduced cytotoxicity in decidual CD56(bright) CD16(-) NK cells. Of interest, decreased TSLP expression and reduced numbers of Tregs were observed at the maternal-fetal interface during miscarriage. Our study identifies a novel feedback loop between embryo-derived trophoblasts and maternal decidual leukocytes, which induces a tolerogenic immune response to ensure a successful pregnancy.
推荐引用方式
GB/T 7714：

Du Mei-Rong,Guo Pei-Fen,Piao Hai-Lan, et al. Embryonic Trophoblasts Induce Decidual Regulatory T Cell Differentiation and Maternal-Fetal Tolerance through Thymic Stromal Lymphopoietin Instructing Dendritic Cells [J].JOURNAL OF IMMUNOLOGY,2014,192(4):1502-1511.
APA：

Du Mei-Rong,Guo Pei-Fen,Piao Hai-Lan,Wang Song-Cun,&Li Da-Jin.(2014).Embryonic Trophoblasts Induce Decidual Regulatory T Cell Differentiation and Maternal-Fetal Tolerance through Thymic Stromal Lymphopoietin Instructing Dendritic Cells .JOURNAL OF IMMUNOLOGY,192(4):1502-1511.
MLA：

Du Mei-Rong, et al. "Embryonic Trophoblasts Induce Decidual Regulatory T Cell Differentiation and Maternal-Fetal Tolerance through Thymic Stromal Lymphopoietin Instructing Dendritic Cells" .JOURNAL OF IMMUNOLOGY 192,4(2014):1502-1511.

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