首页 / 院系成果 / 成果详情页

Cholic acid treatment in LDLR knockout mice induces hypercholesterolemia and atherosclerosis in an FXR-independent mechanism 会议论文

编号：

39a4b771-fe70-4a31-940d-d59966ba822f
作者：

Ruyi Xue;Pu Qin;Ling Dong;Si Zhang;XiZhong Shen
作者单位：

ZhongShan Hospital,Fudan University,Shanghai 200032;Wyeth Research.Cardiovascular & Metabolic Disease Research,Collegeville,PA 19426;
关键词：

Cholic acid;FXR;hypercholesterolemia;atherosclerosis;
会议名称：

第二十一次全国中西医结合肝病学术会议
会议时间：
会议地点：

昆明
出版信息：

2012 年 (195 - 196)
摘要：

Bile acids play important roles in the metabolism of cholesterol and other fat-soluble nutrients by enhancing solubility and activating farnesoid X receptor (FXR).Moreover,excessive amounts of bile acids in the liver and circulation can cause hepatic and endothelial inflammation.To investigate the role of bile acids and FXR in atherosclerosis,LDLR-/-mice were fed a chow diet supplemented with cholic acid (CA) or lithocholic acid (LCA),for 12 weeks.
收起

浏览次数：1  下载次数：0

浏览次数：1

下载次数：0

打印次数：0