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Design and synthesis of magnetic binary metal oxides nanocomposites through dopamine chemistry for highly selective enrichment of phosphopeptides 期刊论文

编号：

39cb9a15-5459-4e4a-ba2f-510185300adf
作者：

Wang, Mengyi^[1,2];Sun, Xueni^[3];Li, Yan(李嫣)^[3]Deng, Chunhui(邓春晖)^[1,2]
语种：

English
期刊：

PROTEOMICS ISSN：1615-9853 2016 年 16 卷 6 期 (915 - 919) ; MAR
收录：
关键词：

Binary metal oxide affinity chromatography Enrichment magG PD (Zr-Ti)O-4 MALDI TOF MASS Phosphopeptides Technology
摘要：

In this work, for the first time, magnetic binary metal oxides nanocomposites which integrated Zr and Ti into one entity on an atomic scale on polydopamine coated magnetic graphene (magG/PD/(Zr-Ti)O-4) was designed and synthesized, and applied to the enrichment of phosphopeptides. The newly prepared magG/PD/(Zr-Ti)O-4 composites gathered the advantages of large surface area, superparamagnetism, biocompatibility and the enhanced affinity properties to phosphopeptides. MagG/PD/ZrO2, magG/PD/TiO2, as well as the simple physical mixture of them were introduced to compare with magG/PD/(Zr-Ti)O-4 composites. High sensitivity (1 pg/L or 4.0 x 10(-11) M) and selectivity (weight ratio of -casein and BSA reached up to 1:8000) toward phosphopeptides were also presented for magG/PD/(Zr-Ti)O-4 composites. Additionally, mouse brain tissue was chose as the real samples to further investigate the phosphopeptides enrichment ability of this new material.
推荐引用方式
GB/T 7714：

Wang Mengyi,Sun Xueni,Li Yan, et al. Design and synthesis of magnetic binary metal oxides nanocomposites through dopamine chemistry for highly selective enrichment of phosphopeptides [J].PROTEOMICS,2016,16(6):915-919.
APA：

Wang Mengyi,Sun Xueni,Li Yan,Deng Chunhui.(2016).Design and synthesis of magnetic binary metal oxides nanocomposites through dopamine chemistry for highly selective enrichment of phosphopeptides .PROTEOMICS,16(6):915-919.
MLA：

Wang Mengyi, et al. "Design and synthesis of magnetic binary metal oxides nanocomposites through dopamine chemistry for highly selective enrichment of phosphopeptides" .PROTEOMICS 16,6(2016):915-919.

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