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Prowashonupana barley dietary fibre reduces body fat and increases insulin sensitivity in Caenorhabditis elegans model 期刊论文

编号：

39dadfba-1c67-4ddf-8049-319d103dbc33
作者：

Gao, Chenfei^[1] King, Michael L.^[2] Fitzpatrick, Zachary L.^[2] Wei, Wenqian^[3] King, Jason F.^[1] Wang, Mingming^[1] Greenway, Frank L.^[4] Finley, John W.^[1] Burton, Jeffrey H.^[4] Johnson, William D.^[4] Keenan, Michael J.^[1,4] Enright, Frederick M.^[5] Martin, Roy J.^[6] Zheng, Jolene^[4]
语种：

English
期刊：

JOURNAL OF FUNCTIONAL FOODS ISSN：1756-4646 2015 年 18 卷 (564 - 574) ; OCT
收录：
关键词：

Obesity Barley Animal models Insulin sensitivity Ageing
摘要：

Prowashonupana barley (PWB) is high in beta-glucan with moderate content of resistant starch. PWB reduced intestinal fat deposition (IFD) in wild type Caenorhabditis elegans (C. elegans, N2), and in sir-2.1 or daf-16 null mutants, and sustained a surrogate marker of lifespan, pharyngeal pumping rate (PPR), in N2, sir-2.1, daf-16, or daf-16/daf-2 mutants. Hyperglycaemia (2% glucose) reversed or reduced the PWB effect on IFD in N2 or daf-16/daf-2 mutants with a sustained PPR. mRNA expression of cpt-1, cpt-2, ckr-1, and gcy-8 were dose-dependently reduced in N2 or daf-16 mutants, elevated in daf-16/daf-2 mutants with reduction in cpt-1, and unchanged in sir-2.1 mutants. mRNA expressions were increased by hyperglycaemia in N2 or daf-16/daf-2 mutants, while reduced in sir-2.1 or daf-16 mutants. The effects of PWB in the C. elegans model appeared to be primarily mediated via sir-2.1, daf-16, and daf-16/daf-2. These data suggest that PWB and beta-glucans may benefit hyperglycaemia-impaired lipid metabolism. (C) 2015 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Gao Chenfei,King Michael L.,Fitzpatrick Zachary L., et al. Prowashonupana barley dietary fibre reduces body fat and increases insulin sensitivity in Caenorhabditis elegans model [J].JOURNAL OF FUNCTIONAL FOODS,2015,18:564-574.
APA：

Gao Chenfei,King Michael L.,Fitzpatrick Zachary L.,Wei Wenqian,&Zheng Jolene.(2015).Prowashonupana barley dietary fibre reduces body fat and increases insulin sensitivity in Caenorhabditis elegans model .JOURNAL OF FUNCTIONAL FOODS,18:564-574.
MLA：

Gao Chenfei, et al. "Prowashonupana barley dietary fibre reduces body fat and increases insulin sensitivity in Caenorhabditis elegans model" .JOURNAL OF FUNCTIONAL FOODS 18(2015):564-574.

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