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A Common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population 期刊论文

编号：

3a8a826f-12bf-4d26-bfe5-00539129ed7b
作者：

Tao, Liming^[2] Zhang, Zhou^[2] Chen, Zhuo^[2] Zhou, Daizhan^[2] Li, Weidong^[3] Kan, Mengyuan^[2] Zhang, Di^[2] He, Lin^[2,3,4] Huang, Guoying^[1,4] Liu, Yun^[4]
语种：

English
期刊：

MOLECULAR BIOLOGY REPORTS ISSN：0301-4851 2012 年 39 卷 6 期 (6487 - 6493) ; JUN
收录：
关键词：

MC4R rs17782313 BMI Lipid concentration
摘要：

A number of recent genome-wide association studies in European populations have reported that variant rs17782313 is significantly associated with obesity and body mass index (BMI). The purpose of the present study was to evaluate the association of rs17782313 with obesity and BMI in the Chinese Han population. We also sought to extend previous studies by determining whether this SNP is associated with plasma lipid levels in the Chinese Han population. Rs17782313 was genotyped in two independent Chinese Han cohorts (Cohort1: n = 2533; Cohort2: n = 2105). In our study, rs17782313 did not show significant association with either obesity or BMI in the Chinese Han population, but showed evidence for association with LDL-C (P similar to 0.003) and TC (P similar to 0.001). Our findings indicate that the variant rs17782313 near MC4R is likely to have an impact on plasma lipid levels of LDL-C and TC in the Chinese Han population.
推荐引用方式
GB/T 7714：

Tao Liming,Zhang Zhou,Chen Zhuo, et al. A Common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population [J].MOLECULAR BIOLOGY REPORTS,2012,39(6):6487-6493.
APA：

Tao Liming,Zhang Zhou,Chen Zhuo,Zhou Daizhan,&Liu Yun.(2012).A Common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population .MOLECULAR BIOLOGY REPORTS,39(6):6487-6493.
MLA：

Tao Liming, et al. "A Common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population" .MOLECULAR BIOLOGY REPORTS 39,6(2012):6487-6493.

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