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Inhibition of Spinal Interlukin-33/ST2 Signaling and Downstream ERK and JNK Pathways in Electroacupuncture Analgesia in Formalin Mice 期刊论文

编号：

3ab4c23b-9df3-4626-bda6-728d72b85159
作者：

Han, Ping^[1,2];Liu, Shenbin^[1];Zhang, Mengting^[1];Zhao, Jing^[1];Wang, Yanqing(王彦青)^[1]Wu, Gencheng(吴根诚)^[1]Mi, Wenli^[1];
语种：

English
期刊：

PLOS ONE ISSN：1932-6203 2015 年 10 卷 6 期 ; JUN 12
收录：
摘要：

Although acupuncture is widely used to manage pain, it remains highly controversial, largely due to the lack of a clear mechanism for its benefits. Here, we investigated the role of IL-33, a novel interleukin (IL)-1 family member, and its receptor ST2 in the analgesic effects of electroacupuncture (EA) on formalin-induced inflammatory pain. The results showed that 1) EA stimulation of ipsilateral Zusanli (ST 36) and Yanglingquan (GB 34) acupoints for 30 min remarkably suppressed the two phases of formalin-induced spontaneous pain; 2) subcutaneous or intrathecal administration of recombinant IL-33 (rIL-33) significantly inhibited the analgesic effect of EA, whereas the ST2 antibody potentiated EA analgesia in formalin mice; 3) EA treatment decreased the up-regulation of IL-33 and ST2 protein following formalin injection; and 4) the suppression of the formalin-induced expression of spinal phosphorylated ERK and JNK induced by EA treatment was significantly attenuated following subcutaneous rIL-33 delivery, and was further decreased by the ST2 antibody. These data suggest that EA alleviates formalin-induced inflammatory pain, at least partially, by inhibiting of spinal IL-33/ST2 signaling and the downstream ERK and JNK pathways.
推荐引用方式
GB/T 7714：

Han Ping,Liu Shenbin,Zhang Mengting, et al. Inhibition of Spinal Interlukin-33/ST2 Signaling and Downstream ERK and JNK Pathways in Electroacupuncture Analgesia in Formalin Mice [J].PLOS ONE,2015,10(6).
APA：

Han Ping,Liu Shenbin,Zhang Mengting,Zhao Jing,&Mi Wenli.(2015).Inhibition of Spinal Interlukin-33/ST2 Signaling and Downstream ERK and JNK Pathways in Electroacupuncture Analgesia in Formalin Mice .PLOS ONE,10(6).
MLA：

Han Ping, et al. "Inhibition of Spinal Interlukin-33/ST2 Signaling and Downstream ERK and JNK Pathways in Electroacupuncture Analgesia in Formalin Mice" .PLOS ONE 10,6(2015).

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