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Association of glutathione S-transferase T1 and M1 polymorphisms with prostate cancer susceptibility in populations of Asian descent: a meta-analysis 期刊论文

编号：

3c1e3145-d6af-4f0b-864c-a072f4305b97
作者：

Cao, DaLong(曹达龙)#^[1,2]Ye, DingWei(叶定伟)*^[1,2]Dai, Bo(戴波)^[1,2]Zhang, HaiLiang(张海梁)^[1,2]Shen, YiJun(沈益君)^[1,2]Zhu, Yao(朱耀)^[1,2]Zhu, YiPing(朱一平)^[1,2]Shi, GuoHai(施国海)^[1,2]Ma, ChunGuang(马春光)^[1,2]Xiao, WenJun(肖文军)^[1,2]Qin, XiaoJian(秦晓健)^[1,2]Lin, GuoWen(林国文)^[1,2]
语种：

English
期刊：

ONCOTARGET ISSN：1949-2553 2015 年 6 卷 34 期 (35843 - 35850) ; NOV 3
收录：
关键词：

prostate cancer susceptibility polymorphism glutathione S-transferases T1 glutathione S-transferases M1
摘要：

Background: Genetic polymorphism was hypothesized to be reason of variation in prostate cancer incidence among different racial group. Based on that published data on the association of prostate cancer susceptibility with polymorphisms in genes encoding Glutathione S-transferases (GSTs) were inconclusive, the aim of this study was to more precisely address the role of GSTs polymorphisms (especially, GSTT1 and GSTM1 deletions) on prostate cancer risk in Asian descent. Methods: A meta-analysis including 8 articles with 711 cases and 1122 controls for GSTT1 and 1098 cases and 1588 controls for GSTM1 was performed. Results: Significantly increased prostate cancer risk was found among subjects carrying GSTM1 null genotype (odds ratio (OR) = 1.403; 95% confidence interval (CI) = 1.088 - 1.808) but not among subjects carrying GSTT1 deletion genotype (OR = 0.959; 95% CI = 0.709 - 1.297). When stratified by country, the null genotype of GSTT1 neither increased nor decreased prostate cancer risk significantly in China (OR = 1.355; 95% CI = 0.895 - 2.049), Japan (OR = 0.812; 95% CI = 0.545 - 1.211), and Korea (OR = 1.056; 95% CI = 0.727 - 1.534). While significant association of elevated prostate cancer risk with GSTM1 deletion were found in China (OR = 1.665; 95% CI = 1.324 - .094) and Korea (OR = 1.914; 95% CI = 1.311 - 2.793) but not in Japan (OR = 0.980; 95% CI = 0.726 - 1.321). Conclusion: In summary, this meta-analysis suggested that the null genotype of GSTM1 rather than GSTT1 may be involved in the etiology of prostate cancer in Asian population.
推荐引用方式
GB/T 7714：

Cao Da-Long,Ye Ding-Wei,Dai Bo, et al. Association of glutathione S-transferase T1 and M1 polymorphisms with prostate cancer susceptibility in populations of Asian descent: a meta-analysis [J].ONCOTARGET,2015,6(34):35843-35850.
APA：

Cao Da-Long,Ye Ding-Wei,Dai Bo,Zhang Hai-Liang,&Lin Guo-Wen.(2015).Association of glutathione S-transferase T1 and M1 polymorphisms with prostate cancer susceptibility in populations of Asian descent: a meta-analysis .ONCOTARGET,6(34):35843-35850.
MLA：

Cao Da-Long, et al. "Association of glutathione S-transferase T1 and M1 polymorphisms with prostate cancer susceptibility in populations of Asian descent: a meta-analysis" .ONCOTARGET 6,34(2015):35843-35850.

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