首页 / 院系成果 / 成果详情页

Feasibility of Tc-99m-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas 期刊论文

编号：

3cd2ff24-d7b6-4baa-aeba-b44055b70706
作者：

Zhao Juan^[1];Qi Yujin^[2];Dai Qiusheng^[2];Zhang Xuezhu^[2];Qu Xiaomei^[3];Huang Jia^[3];Liu Xingdang(刘兴党)*^[1]
语种：

English
期刊：

NUCLEAR SCIENCE AND TECHNIQUES ISSN：1001-8042 2008 年 19 卷 2 期 (105 - 108) ; APR 20
收录：
关键词：

Micro-SPECT Tc-99m-TRODAT-1 dopamine transporter form deprivation myopia guinea pig
摘要：

In this paper, Tc-99m-TRODAT-1 Micro-SPECT (single-photon emission computed tomography) was used for imaging dopamine transporter (DAT) in retinas and to investigate the changes of DAT in retinas of pigs with form deprivation myopia. Pigmented guinea pigs aged 3 weeks were devided into form deprivation myopia (FDM) group (n=6) and normal control group (n=6). The test group wore translucent goggles randomly for 4 weeks, and both groups underwent biometric measurement (refraction and axial length) before and after the experiment. Micro-SPECT retinas imaging was performed at the 4(th) week after injection of Tc-99m-TRODAT-1. The retinas were clearly resolved in the images. The ratio of Tc-99m-TRODAT-1 uptake in the myopic retinas (11.55 +/- 2.80) was 3.64 +/- 1.40 lower than that in the control eye (15.20 +/- 1.98), and 2.35 +/- 1.05 lower than that in the fellow eyes (13.90 +/- 2.04). The results showed that Tc-99m-TRODAT-1 Micro-SPECT eye imaging can be used to trace the distribution and changes of DAT in retina, and DAT in the myopic retinas were lower than that in the normal control eyes and fellow eyes. Micro-SPECT may provide a new approach for further studies on the role of dopamine system in the experimental myopia.
推荐引用方式
GB/T 7714：

Zhao Juan,Qi Yujin,Dai Qiusheng, et al. Feasibility of Tc-99m-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas [J].NUCLEAR SCIENCE AND TECHNIQUES,2008,19(2):105-108.
APA：

Zhao Juan,Qi Yujin,Dai Qiusheng,Zhang Xuezhu,&Liu Xingdang.(2008).Feasibility of Tc-99m-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas .NUCLEAR SCIENCE AND TECHNIQUES,19(2):105-108.
MLA：

Zhao Juan, et al. "Feasibility of Tc-99m-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas" .NUCLEAR SCIENCE AND TECHNIQUES 19,2(2008):105-108.

浏览次数：3  下载次数：0

分享到：

浏览次数：3

下载次数：0

打印次数：0