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Divergent syntheses of L-733, 060 and CP-122721 from functionalized pieridinones made by one-pot tandem cyclization 期刊论文

编号：

3e55843a-8073-4765-b47c-8dd2218fdc42
作者：

Liu, YiWen^[1,2];Mao, ZhuoYa(毛卓亚)^[1,2]Ma, RuiJun^[3];Yan, JiaHang^[1,2];Si, ChangMei(司长梅)*^[1,2]Wei, BangGuo(魏邦国)*^[1,2]
语种：

English
期刊：

TETRAHEDRON ISSN：0040-4020 2017 年 73 卷 15 期 (2100 - 2108) ; APR 13
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关键词：

Asymmetric synthesis Tandem process 2-Piperidinone (+)-L-733, 060 (+)-CP-122721
摘要：

An efficient diastereoselective approach to access trans-5-hydroxy-6-substituted 2-piperidinones skeleton has been developed through one-pot intramolecular tandem process of O-benzyl protected aldimine 11 with Grignard reagents. The diastereoselectivity of substitution at C-6 position of 2-piperidinone was controlled by alpha-benzyloxy group. In addition, the utility of this straightforward cascade process is demonstrated by the asymmetric syntheses of (+)-L-733, 060 (2) and its 2-substituted analogue 3, as well as (+)-CP-122721 (5). (C) 2017 Published by Elsevier Ltd.
推荐引用方式
GB/T 7714：

Liu Yi-Wen,Mao Zhuo-Ya,Ma Rui-Jun, et al. Divergent syntheses of L-733, 060 and CP-122721 from functionalized pieridinones made by one-pot tandem cyclization [J].TETRAHEDRON,2017,73(15):2100-2108.
APA：

Liu Yi-Wen,Mao Zhuo-Ya,Ma Rui-Jun,Yan Jia-Hang,&Wei Bang-Guo.(2017).Divergent syntheses of L-733, 060 and CP-122721 from functionalized pieridinones made by one-pot tandem cyclization .TETRAHEDRON,73(15):2100-2108.
MLA：

Liu Yi-Wen, et al. "Divergent syntheses of L-733, 060 and CP-122721 from functionalized pieridinones made by one-pot tandem cyclization" .TETRAHEDRON 73,15(2017):2100-2108.

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