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2 pathway 期刊论文

编号：

3e90e37a-14df-48dc-b80f-c43e3253a36c
作者：

Lu, Zhengyu^[1];Liu, Yanping^[3];Shi, Yang^[1];Shi, Xinjie^[1];Wang, Xin^[1];Xu, Chuan^[1];Zhao, Hong^[1];Dong, Qiang(董强)*^[2]
语种：

English
期刊：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN：0006-291X 2018 年 496 卷 2 期 (515 - 522) ; FEB 5
收录：
关键词：

Curcumin Cortical neurons Oxygen and glucose deprivation/reoxygenation Flotillin-1 Mitogen-activated protein kinase
摘要：

In this study, we provided evidence that curcumin could be a promising therapeutic agent for ischemic stroke by activating neuroprotective signaling pathways. Post oxygen and glucose deprivation/reoxygenation (OGD/R), primary mouse cortical neurons treated with curcumin exhibited a significant decrease in cell death, LDH release and enzyme caspase-3 activity under OGD/R circumstances, which were abolished by flotillin-1 downregulation or extracellular signal-regulated kinase (ERK) inhibitor. Moreover, flotillin-1 knockdown led to suppression of curcumin-mediated ERK phosphorylation under OGD/R condition. Based on these findings, we concluded that curcumin could confer neuroprotection against OGD/R injury through a novel flotillin-1 and ERK1/2 pathway. (C) 2018 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Lu Zhengyu,Liu Yanping,Shi Yang, et al. Curcumin protects cortical neurons against oxygen and glucose deprivation/reoxygenation injury through flotillin-1 and extracellular signal-regulated kinase1/2 pathway [J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,496(2):515-522.
APA：

Lu Zhengyu,Liu Yanping,Shi Yang,Shi Xinjie,&Dong Qiang.(2018).Curcumin protects cortical neurons against oxygen and glucose deprivation/reoxygenation injury through flotillin-1 and extracellular signal-regulated kinase1/2 pathway .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,496(2):515-522.
MLA：

Lu Zhengyu, et al. "Curcumin protects cortical neurons against oxygen and glucose deprivation/reoxygenation injury through flotillin-1 and extracellular signal-regulated kinase1/2 pathway" .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 496,2(2018):515-522.

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