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Genetic diversity in Puerto Rico and its implications for the peopling of the Island and the West Indies 期刊论文

编号：

3febdeab-7caa-418b-9608-0cf05c90c0d3
作者：

Vilar, Miguel G.[0]^[1] Melendez, Carlalynne[1]^[2] Sanders, Akiva B.[2]^[3] Walia, Akshay[3]^[3] Gaieski, Jill B.[4]^[3] Owings, Amanda C.[5]^[3] Schurr, Theodore G.[6]^[3] Adhikarla, Syama[7]^[4] Adler, Christina J.[8]^[5] Balanovska, Elena V.[9]^[6] Balanovsky, Oleg P.[10]^[6] Bertranpetit, Jaume[11]^[7] Clarke, Andrew C.[12]^[8] Comas, D.[13]^[7] Cooper, Alan[14]^[9] Der Sarkissian, Clio S.I.[15]^[10] GaneshPrasad, Arun Kumar[16]^[4] Haak, Wolfgang[17]^[11] Haber, Marc[18]^[7] Hobbs, Angela[19]^[12] Javed, Asif[20]^[13] Jin, Li[21]^[14] Kaplan, Matthew E.[22]^[15] Li, Shilin[23]^[16] MartínezCruz, Bego?a[24]^[7] MatisooSmith, Elizabeth A.[25]^[8] Melé, Marta[26]^[7] Merchant, Nirav C.[27]^[15] Mitchell, Robert John[28]^[17] Parida, Laxmi P.[29]^[13] Pitchappan, Ramasamy M.[30]^[4] Platt, Daniel E.[31]^[18] QuintanaMurci, Lluís[32]^[19] RENFREW, Colin[33]^[20] Lacerda, Daniela Rodrigues[34]^[21] Royyuru, Ajay K.[35]^[13] Santos, Fabrício Rodrigues Dos[36]^[21] Soodyall, Himla[37]^[22] SoriaHernanz, David F.[38]^[1] Swamikrishnan, Pandikumar[39]^[13] TylerSmith, Chris[40]^[23] Santhakumari, Arun Varatharajan[41]^[4] Vieira, Pedro Paulo Ribeiro[42]^[21] Wells, Rachel Spencer[43]^[1] Zalloua, Pierre[44]^[24] Ziegle, Janet S.[45]^[25]
地址：

[1]National Geographic Society,Washington,United States
[2]University of Pennsylvania, National Geographic Society,Philadelphia,United States
[3]University of Pennsylvania, Department of Anthropology,Philadelphia,United States
[4]Madurai Kamaraj University,Madurai,India
[5]University of Adelaide,Adelaide,Australia
[6]Research Centre for Medical Genetics,Moscow,Russian Federation
[7]Universitat Pompeu Fabra,Barcelona,Spain
[8]University of Otago,Dunedin,New Zealand
[9]University of Adelaide, Australian Centre for Ancient DNA,Adelaide,Australia
[10]Kobenhavns Universitet, Centre for GeoGenetics,Copenhagen,Denmark
[11]Max Planck Institute for the Science of Human History, Department for Archaeogenetics,Jena,Germany
[12]National Health Laboratory Services,Johannesburg,South Africa
[13]International Business Machines,Armonk,United States
[14]Fudan University, School of Life Sciences,Shanghai,China
[15]University of Arizona,Tucson,United States
[16]Fudan University, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology,Shanghai,China
[17]La Trobe University,Melbourne,Australia
[18]IBM Thomas J. Watson Research Center,Yorktown Heights,United States
[19]Institut Pasteur, Paris, Unit of Human Evolutionary Genetics,Paris,France
[20]University of Cambridge,Cambridge,United Kingdom
[21]Universidade Federal de Minas Gerais, Departamento de Biologia Geral,Belo Horizonte,Brazil
[22]National Health Laboratory Services, Division of Human Genetics,Johannesburg,South Africa
[23]Wellcome Trust Sanger Institute,Cambridge,United Kingdom
[24]Harvard University,Cambridge,United States
[25]Applied Biosystems USA,Foster City,United States
语种：

英文
期刊：

American Journal of Physical Anthropology ISSN：0002-9483 2014 年 155 卷 3 期 (352 - 368)
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关键词：

Caribbean Haplogroup Haplotype Migration mtDNA Y-chromosome
摘要：

Puerto Rico and the surrounding islands rest on the eastern fringe of the Caribbean"s Greater Antilles, located less than 100 miles northwest of the Lesser Antilles. Puerto Ricans are genetic descendants of pre-Columbian peoples, as well as peoples of European and African descent through 500 years of migration to the island. To infer these patterns of pre-Columbian and historic peopling of the Caribbean, we characterized genetic diversity in 326 individuals from the southeastern region of Puerto Rico and the island municipality of Vieques. We sequenced the mitochondrial DNA (mtDNA) control region of all of the samples and the complete mitogenomes of 12 of them to infer their putative place of origin. In addition, we genotyped 121 male samples for 25 Y-chromosome single nucleotide polymorphism and 17 STR loci. Approximately 60% of the participants had indigenous mtDNA haplotypes (mostly from haplogroups A2 and C1), while 25% had African and 15% European haplotypes. Three A2 sublineages were unique to the Greater Antilles, one of which was similar to Mesoamerican types, while C1b haplogroups showed links to South America, suggesting that people reached the island from the two distinct continental source areas. However, none of the male participants had indigenous Y-chromosomes, with 85% of them instead being European/Mediterranean and 15% sub-Saharan African in origin. West Eurasian Y-chromosome short tandem repeat haplotypes were quite diverse and showed similarities to those observed in southern Europe, North Africa and the Middle East. These results attest to the distinct, yet equally complex, pasts for the male and female ancestors of modern day Puerto Ricans. © 2014 Wiley Periodicals, Inc.
推荐引用方式
GB/T 7714：

Vilar Miguel G./15133305700[0],Melendez Carlalynne/56149942900[1],Sanders Akiva B./56393901300[2], et al. Genetic diversity in Puerto Rico and its implications for the peopling of the Island and the West Indies [J].American Journal of Physical Anthropology,2014,155(3):352-368.
APA：

Vilar Miguel G./15133305700[0],Melendez Carlalynne/56149942900[1],Sanders Akiva B./56393901300[2],Walia Akshay/56394206600[3],&Ziegle Janet S./6603590396[45].(2014).Genetic diversity in Puerto Rico and its implications for the peopling of the Island and the West Indies .American Journal of Physical Anthropology,155(3):352-368.
MLA：

Vilar Miguel G./15133305700[0], et al. "Genetic diversity in Puerto Rico and its implications for the peopling of the Island and the West Indies" .American Journal of Physical Anthropology 155,3(2014):352-368.

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