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Highly Penetrant Alterations of a Critical Region Including BDNF in Human Psychopathology and Obesity 期刊论文

编号：

404005c3-36cd-4b99-82e6-cfeecd55035e
作者：

Ernst, Carl^[1,9,17] Marshall, Christian R.^[7] Shen, Yiping^[12,20] Metcalfe, Kay^[21] Rosenfeld, Jill^[22] Hodge, Jennelle C.^[23] Torres, Alcy^[13] Blumenthal, Ian Chiang, Colby Pillalamarri, Vamsee Crapper, Liam^[1] Diallo, Alpha B.^[1] Ruderfer, Douglas Pereira, Shahrin^[16] Sklar, Pamela^[24] Purcell, Shaun Wildin, Robert S.^[25,26] Spencer, Anne C.^[27] Quade, Bradley F.^[15,16] Harris, David J.^[12,14] Lemyre, Emanuelle^[2] Wu, Bailin^[12,18,19] Stavropoulos, Dimitri J.^[4] Geraghty, Michael T.^[6] Shaffer, Lisa G.^[22] Morton, Cynthia C.^{[10,15,16,17]} Scherer, Stephen W.^[3,5,7] Gusella, James F.^[9,11,17] Talkowski, Michael E.^[8,9,17]
语种：

English
期刊：

ARCHIVES OF GENERAL PSYCHIATRY ISSN：0003-990X 2012 年 69 卷 12 期 (1238 - 1246) ; DEC
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摘要：

Context: Brain-derived neurotrophic factor (BDNF) is suspected of being a causative factor in psychiatric disorders based on case reports or studies involving large structural anomalies. Objective: To determine the involvement of BDNF in human psychopathology. Design: Case-control study. Setting: Microarray-based comparative genomic hybridization data from 7 molecular diagnostic centers including 38 550 affected subjects and 28 705 unaffected subjects. Patients: Subjects referred to diagnostic screening centers for microarray-based comparative genomic hybridization for physical or cognitive impairment. Main Outcome Measures: Genomic copy number gains and losses. Results: We report 5 individuals with psychopathology and genomic deletion of a critical region including BDNF. The defined critical region was never disrupted in control subjects or diagnostic cases without developmental abnormalities. Conclusion: Hemizygosity of the BDNF region contributes to variable psychiatric phenotypes including anxiety, behavioral, and mood disorders.
推荐引用方式
GB/T 7714：

Ernst Carl,Marshall Christian R.,Shen Yiping, et al. Highly Penetrant Alterations of a Critical Region Including BDNF in Human Psychopathology and Obesity [J].ARCHIVES OF GENERAL PSYCHIATRY,2012,69(12):1238-1246.
APA：

Ernst Carl,Marshall Christian R.,Shen Yiping,Metcalfe Kay,&Talkowski Michael E..(2012).Highly Penetrant Alterations of a Critical Region Including BDNF in Human Psychopathology and Obesity .ARCHIVES OF GENERAL PSYCHIATRY,69(12):1238-1246.
MLA：

Ernst Carl, et al. "Highly Penetrant Alterations of a Critical Region Including BDNF in Human Psychopathology and Obesity" .ARCHIVES OF GENERAL PSYCHIATRY 69,12(2012):1238-1246.

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