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The leukotriene B-4-leukotriene B-4 receptor axis promotes cisplatin-induced acute kidney injury by modulating neutrophil recruitment 期刊论文

编号：

409c03eb-14eb-44ee-8a32-75575915a313
作者：

Deng, Bo^[1];Lin, Yuli(林玉丽)^[2]Ma, Shuai^[1];Zheng, Yin^[3];Yang, Xuguang^[4];Li, Bingji(李冰骥)^[2]Yu, Wenyan^[1];Xu, Qingqing^[1];Liu, Tingyan^[1];Hao, Chuanming(郝传明)^[3]He, Rui(何睿)*^[2]Ding, Feng^[1];
语种：

English
期刊：

KIDNEY INTERNATIONAL ISSN：0085-2538 2017 年 92 卷 1 期 (89 - 100) ; JUL
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关键词：

acute kidney injury cisplatin nephrotoxicity leukotriene B-4 leukotriene B-4 receptor 1 neutrophils
摘要：

Cisplatin is an effective chemotherapeutic agent and widely used in treatment of various solid organ malignancies, including head and neck, ovarian, and testicular cancers. However, the induction of acute kidney injury (AKI) is one of its main side effects. Leukotriene B-4 receptor 1 (BLT1) mediates the majority of physiological effects of leukotriene B-4 (LTB4), a potent lipid chemoattractant generated at inflammation sites, but the role of the LTB4-BLT1 axis in cisplatin-induced AKI remains unknown. Here we found upregulated LTB4 synthesis and BLT1 expression in the kidney after cisplatin administration. Cisplatin was found to directly upregulate gene expression of leukotriene A(4) hydrolase and stimulate LTB4 production in renal tubular epithelial cells. Reduced kidney structural/functional damage, inflammation, and apoptosis were observed in BLT1(-/-) mice, as well as in wild-type mice treated with the LTA4H inhibitor SC-57461A and the BLT1 antagonist U-75302. Neutrophils were likely the target of this pathway, as BLT1 absence induced a significant decrease in infiltrating neutrophils in the kidney. Adoptive transfer of neutrophils from wild-type mice restored kidney injury in BLT1(-/-)mice following cisplatin challenge. Thus, the LTB4-BLT1 axis contributes to cisplatin-induced AKI by mediating kidney recruitment of neutrophils, which induce inflammation and apoptosis in the kidney. Hence, the LTB4-BLT1 axis could be a potential therapeutic target in cisplatin-induced AKI.
推荐引用方式
GB/T 7714：

Deng Bo,Lin Yuli,Ma Shuai, et al. The leukotriene B-4-leukotriene B-4 receptor axis promotes cisplatin-induced acute kidney injury by modulating neutrophil recruitment [J].KIDNEY INTERNATIONAL,2017,92(1):89-100.
APA：

Deng Bo,Lin Yuli,Ma Shuai,Zheng Yin,&Ding Feng.(2017).The leukotriene B-4-leukotriene B-4 receptor axis promotes cisplatin-induced acute kidney injury by modulating neutrophil recruitment .KIDNEY INTERNATIONAL,92(1):89-100.
MLA：

Deng Bo, et al. "The leukotriene B-4-leukotriene B-4 receptor axis promotes cisplatin-induced acute kidney injury by modulating neutrophil recruitment" .KIDNEY INTERNATIONAL 92,1(2017):89-100.

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