Virulence factors (VFs) are molecules that allow microbial pathogens to overcome host defense mechanisms and cause disease in a host. It is critical to study VFs for better understanding microbial pathogenesis and host defense mechanisms. Victors (http://www.phidias.us/victors) is a novel, manually curated, web-based integrative knowledge base and analysis resource for VFs of pathogens that cause infectious diseases in human and animals. Currently, Victors contains 5296 VFs obtained via manual annotation from peer-reviewed publications, with 4648, 179, 105 and 364 VFs originating from 51 bacterial, 54 viral, 13 parasitic and 8 fungal species, respectively. Our data analysis identified many VF-specific patterns. Within the global VF pool, cytoplasmic proteins were more common, while adhesins were less common compared to findings on protective vaccine antigens. Many VFs showed homology with host proteins and the human proteins interacting with VFs represented the hubs of human-pathogen interactions. All Victors data are queriable with a user-friendly web interface. The VFs can also be searched by a customized BLAST sequence similarity searching program. These VFs and their interactions with the host are represented in a machine-readable Ontology of Host-Pathogen Interactions. Victors supports the One Health' research as a vital source of VFs in human and animal pathogens.
[1]Univ Michigan, Med Sch, Dept Microbiol & Immunol, Unit Lab Anim Med, Ann Arbor, MI 48109 USA;
[2]Univ Michigan, Med Sch, Ctr Computat Med & Bioinformat, Ann Arbor, MI 48109 USA;
[3]Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, CAS Ctr Excellence Mol Cell Sci,Key Lab Syst Biol, Shanghai 200031, Peoples R China;
[4]Jiangxi Agr Univ, Dept Vet Med, Nanchang 330045, Jiangxi, Peoples R China;
[5]Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou 350013, Fujian, Peoples R China;
[6]Univ Michigan Hlth Syst, Dept Internal Med, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA;
[7]VA Ann Arbor Hlth Syst, Res Serv, Ann Arbor, MI 48109 USA;
[8]Beijing Municipal Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100097, Peoples R China;
[9]Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai 200433, Peoples R China;
[10]Chinese Acad Sci, CAS Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China;
[11]Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
(8.0+极速模式)