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Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin 期刊论文

编号：

413e5f0d-13b8-4ccb-9e0b-a9949cb1da8f
作者：

Zhou, Pengfei^[1];Liu, Yan^[2];Zhou, Lu(周璐)^[1]Zhu, Kongkai^[2];Feng, Kechang^[1];Zhang, Hao^[2];Liang, Yuru^[1];Jiang, Hualiang^[2];Luo, Cheng^[2];Liu, Mingming(刘明明)*^[1]Wang, Yang(王洋)*^[1]
语种：

English
期刊：

JOURNAL OF MEDICINAL CHEMISTRY ISSN：0022-2623 2016 年 59 卷 22 期 (10329 - 10334) ; NOV 24
收录：
摘要：

A series of chiral,beta-lactam bridged analogues (3-substituted 1,4-diaryl-2-azetidinones) of combretastatin A-4 (CA-4) were synthesized asymmetrically, and their antitumor activities were evaluated in vitro and in vivo. The cocrystal structure of tubulin in complex with compound 9 was determined by X-ray crystallography, which showed that 9 binds to the same site as colchicine with similar binding mode, and the absolute configuration of its C-4 was first identified and demonstrated to be critically important for their antiproliferative activities.
推荐引用方式
GB/T 7714：

Zhou Pengfei,Liu Yan,Zhou Lu, et al. Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin [J].JOURNAL OF MEDICINAL CHEMISTRY,2016,59(22):10329-10334.
APA：

Zhou Pengfei,Liu Yan,Zhou Lu,Zhu Kongkai,&Wang Yang.(2016).Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin .JOURNAL OF MEDICINAL CHEMISTRY,59(22):10329-10334.
MLA：

Zhou Pengfei, et al. "Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin" .JOURNAL OF MEDICINAL CHEMISTRY 59,22(2016):10329-10334.

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