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An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR gamma Ubiquitination 期刊论文

编号：

429a7832-54f9-4622-851f-ddc19bb9f095
作者：

Peng, Jiangtong^[1,2,10] Li, Yutian^[2] Wang, Xiaohong^[2] Deng, Shan^[1,2,10] Holland, Jenna^[3] Yates, Emily^[3] Chen, Jing^[4] Gu, Haitao^[2] Essandoh, Kobina^[2] Mu, Xingjiang^[2] Wang, Boyu^[5] Mcnamara, Robert K.^[6] Peng, Tianqing^[7] Jegga, Anil G.^[4] Liu, Tiemin^[11] Nakamura, Takahisa^[8,9] Huang, Kai^[1,10] PerezTilve, Diego^[3] Fan, GuoChang^[2]
语种：

English
期刊：

CELL REPORTS ISSN：2211-1247 2018 年 23 卷 12 期 (3607 - 3620) ; JUN 19
收录：
摘要：

Exposure to cold temperature is well known to upregulate heat shock protein (Hsp) expression and recruit and/or activate brown adipose tissue and beige adipocytes in humans and animals. However, whether and how Hsps regulate adipocyte function for energy homeostatic responses is poorly understood. Here, we demonstrate a critical role of Hsp20 as a negative regulator of adipocyte function. Deletion of Hsp20 enhances non-shivering thermogenesis and suppresses inflammatory responses, leading to improvement of glucose and lipid metabolism under both chow diet and high-fat diet conditions. Mechanistically, Hsp20 controls adipocyte function by interacting with the subunit of the ubiquitin ligase complex, F-box only protein 4 (FBXO4), and regulating the ubiquitin-dependent degradation of peroxisome proliferation activated receptor gamma (PPAR gamma). Indeed, Hsp20 deficiency mimics and enhances the pharmacological effects of the PPAR gamma agonist rosiglitazone. Together, our findings suggest a role of Hsp20 in mediating adipocyte function by linking beta-adrenergic signaling to PPAR gamma activity.
推荐引用方式
GB/T 7714：

Peng Jiangtong,Li Yutian,Wang Xiaohong, et al. An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR gamma Ubiquitination [J].CELL REPORTS,2018,23(12):3607-3620.
APA：

Peng Jiangtong,Li Yutian,Wang Xiaohong,Deng Shan,&Fan Guo-Chang.(2018).An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR gamma Ubiquitination .CELL REPORTS,23(12):3607-3620.
MLA：

Peng Jiangtong, et al. "An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR gamma Ubiquitination" .CELL REPORTS 23,12(2018):3607-3620.

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