Objective To explore the effect of APOE polymorphisms on patients with cognitive impairments in The Chinese Han population. Materials and methods A total of 1027 cases with Alzheimer's disease (AD), 40 cases with vascular dementia (VaD), 28 cases with behavioral variant frontotemporal dementia (bvFTD), 54 cases with semantic dementia (SD), 44 cases with dementia with Lewy bodies (DLB), 583 cases with mild cognitive impairment (MCI), and 32 cases with vascular cognitive impairment no dementia (VCIND) were recruited consecutively from memory disorders clinics in Huashan Hospital between January 2010 and December 2014. The 1149 cognitively normal controls were recruited from the community epidemiologic investigations. The APOE genotypes were determined using the TaqMan assay. Results The distribution of genotype and allele frequencies of APOE differed significantly between control and AD or MCI, with epsilon 4 increasing the risk of AD and MCI in a dose-dependent pattern and epsilon 2 decreasing the risk of AD, but not the risk of MCI. As for VaD, significant differences in the APOE genotype distribution were found compared with the controls. E4/4 increased the risk of VaD and epsilon 4 increased the risk of VCIND in women. The allele distribution differed between bvFTD and controls, but genotype and allele frequencies of APOE did not affect the risk of bvFTD, SD, and DLB. Conclusion In The Chinese Han population, APOE epsilon 4 increased the risk of AD and MCI in a dose-dependent manner and epsilon 2 decreased the risk of AD as reported previously. APOE epsilon 4 might increase risk in VaD and female patients with VCIND, but no effects of APOE on bvFTD, DLB, and SD were found. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
[1]Fudan Univ, Dept Neurol, Huashan Hosp, Shanghai Med Coll, 12 Wulumuqi Zhong Rd, Shanghai 200040, Peoples R China.
[2]Fudan Univ, Inst Neurol, Huashan Hosp, Shanghai Med Coll, 12 Wulumuqi Zhong Rd, Shanghai 200040, Peoples R China.
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