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Naive Treg-like CCR7(+) mononuclear cells indicate unfavorable prognosis in hepatocellular carcinoma 期刊论文

编号：

4502f0bc-62e7-4cd3-a304-a83350d88e6b
作者：

Shi, JieYi^[1];Duan, Meng^[1];Sun, QiMan^[1];Yang, Liuxiao^[1];Wang, ZhiChao^[1];Mynbaev, Ospan A.^[2,3];He, YiFeng^[1];Wang, LingYan^[4];Zhou, Jian^[1,5];Tang, QiQun(汤其群)^[6]Cao, Ya^[7];Fan, Jia^[1,5];Wang, XiaoYing^[1,8];Gao, Qiang(高强)*^[1,4,8]
语种：

English
期刊：

TUMOR BIOLOGY ISSN：1010-4283 2016 年 37 卷 7 期 (9909 - 9917) ; JUL
收录：
关键词：

CCR7 CCRL1 Treg-like Tumor microenvironment
摘要：

Chemokine receptor-like 1 (CCRL1) has the potential in creating a low level of CCL19 and CCL21 to hinder CCR7(+) cell tracking to tumor tissue. Previously, we found a tumor suppressive role of CCRL1 by impairing CCR7-related chemotaxis of tumor cells in human hepatocellular carcinoma (HCC). Here, we reported a contribution of CCR7(+) mononuclear cells in the tumor microenvironment to the progression of disease. Immunohistochemistry was used to investigate the distribution and clinical significance of CCR7(+) cells in a cohort of 240 HCC patients. Furthermore, the phenotype, composition, and functional status of CCR7(+) cells were determined by flow cytometry, immunofluorescence, and in vitro co-culture assays. We found that CCR7(+) mononuclear cells were dispersed around tumor tissue and negatively related to tumoral expression of CCRL1 (P < 0.001, r = 0.391). High density of CCR7(+) mononuclear cells positively correlated with the absence of tumor capsule, vascular invasion, and poor differentiation (P < 0.05). Survival analyses revealed that increased number of CCR7(+) mononuclear cells was significantly associated with worse survival and increased recurrence. We found that CCR7(+) mononuclear cells featured a naive Treg-like phenotype (CD45RA(+)CD25(+)FOXP3(+)) and possessed tumor-promoting potential by producing TGF-beta 1. Moreover, CCR7(+) cells were also composed of several immunocytes, a third of which were CD8(+) T cells. CCR7(+) Treg-like cells facilitate tumor growth and indicate unfavorable prognosis in HCC patients, but fortunately, their tracking to tumor tissue is under the control of CCRL1.
推荐引用方式
GB/T 7714：

Shi Jie-Yi,Duan Meng,Sun Qi-Man, et al. Naive Treg-like CCR7(+) mononuclear cells indicate unfavorable prognosis in hepatocellular carcinoma [J].TUMOR BIOLOGY,2016,37(7):9909-9917.
APA：

Shi Jie-Yi,Duan Meng,Sun Qi-Man,Yang Liuxiao,&Gao Qiang.(2016).Naive Treg-like CCR7(+) mononuclear cells indicate unfavorable prognosis in hepatocellular carcinoma .TUMOR BIOLOGY,37(7):9909-9917.
MLA：

Shi Jie-Yi, et al. "Naive Treg-like CCR7(+) mononuclear cells indicate unfavorable prognosis in hepatocellular carcinoma" .TUMOR BIOLOGY 37,7(2016):9909-9917.

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