Background: Few data are available on centraleline associated bloodstream infections (CLABSIs) in Chinese neonatal intensive care units (NICUs). The aims of this study were to characterize CLABSIs among neonates in a Chinese NICU and evaluate the impact of a multifaceted evidence-based practice for improving quality program to decrease CLABSI. Methods: We conducted a prospective before-after intervention study with a 1-year follow-up among patients with central lines at the NICU of the Children's Hospital of Fudan University between January 2008 and December 2010. The study was conducted in 3 phases: before, during, and after the intervention. A multifaceted infection control program was introduced in phase 2 with successive surveillance. CLABSIs were prospectively monitored and compared. Results: A total of 171 patients with central lines (CLs) were observed; 29 of them developed CLABSI corresponding to 7.35 per 1,000 catheter days, with a CL utilization ratio of 37.9%. Overall CLABSI rate decreased gradually from 16.7 per 1,000 CL days in phase 1 to 7.6 per 1,000 CL days in phase 2 (P=.08) to 5.2 per 1,000 CL days in phase 3 (P <.01). Gram-negative bacterium (54.5%) was the predominant pathogen in CLABSIs. Conclusion: A multifaceted infection control program is effective in reducing the CLABSI rate among neonates. Such interventions could be extended to other resource-limited countries. Copyright (C) 2015 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
[1]Fudan Univ, Childrens Hosp, Dept Neonatol, Shanghai 201102, Peoples R China.
[2]Univ Toronto, Dept Pediat, Toronto, ON, Canada.
[3]Fudan Univ, Childrens Hosp, Dept Microbiol, Shanghai 201102, Peoples R China.
(8.0+极速模式)