首页 / 院系成果 / 成果详情页

Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4(+) T cells 期刊论文

编号：

4724985c-c5c8-4a2d-a9a4-d03d18d52d96
作者：

Xu, Hongwei^[1,2,4] Wu, ZhiYing^[1,2,11,12] Fang, Fang^[1,2] Guo, Lan^[1,2] Chen, Doris^[1,2] Chen, John Xi^[5] Stern, David^[6] Taylor, Gregory A.^[7,8,9,10] Jiang, Hong^[3] Yan, Shirley ShiDu^[1,2]
语种：

English
期刊：

FASEB JOURNAL ISSN：0892-6638 2010 年 24 卷 5 期 (1583 - 1592) ; MAY
收录：
关键词：

IFN-gamma-mediated apoptosis EAE/MS animal model
摘要：

The immunity-related GTPase Irgm1, also called LRG-47, is known to regulate host resistance to intracellular pathogens through multiple mechanisms that include controlling the survival of T lymphocytes. Here, we address whether Irgm1 also plays a role in the pathogenesis of experimental autoimmune encephalitis (EAE). We find that Irgm1/LRG-47 is a significant factor in the progression of EAE and multiple sclerosis (MS). Expression of Irgm1 was robustly elevated in MS-affected lesions and in the central nervous system (CNS) of myelin basic protein (MBP)-induced EAE mice, especially in cells of lymphoid and mononuclear phagocyte origin. Homozygous Irgm1 null mice were resistant to MBP-induced EAE, and CD4(+) T cells in spleen and CNS of these mice displayed decreased proliferative capacity, increased apoptosis, and up-regulated interferon (IFN)-gamma induction. Therefore, Irgm1-induced survival of autoreactive CD4(+) T cells contributes significantly to the pathogenesis of EAE. Blockade of Irgm1 may be a potential therapeutic strategy for halting multiple sclerosis.-Xu, H., Wu, Z.-Y., Fang, F., Guo, L., Chen, D., Chen, J. X., Stern, D., Taylor, G. A., Jiang, H., Yan, S. S. Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4(+) T cells. FASEB J. 24, 1583-1592 (2010). www.fasebj.org
推荐引用方式
GB/T 7714：

Xu Hongwei,Wu Zhi-Ying,Fang Fang, et al. Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4(+) T cells [J].FASEB JOURNAL,2010,24(5):1583-1592.
APA：

Xu Hongwei,Wu Zhi-Ying,Fang Fang,Guo Lan,&Yan Shirley ShiDu.(2010).Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4(+) T cells .FASEB JOURNAL,24(5):1583-1592.
MLA：

Xu Hongwei, et al. "Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4(+) T cells" .FASEB JOURNAL 24,5(2010):1583-1592.

浏览次数：1  下载次数：0

分享到：

浏览次数：1

下载次数：0

打印次数：0