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Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase 期刊论文

编号：

486e24c1-942e-4b4c-907d-094dd26bb297
作者：

He, Xiaozhen^[1,2,3,4];Yan, Bin^[1,2,3,4];Liu, Shuang^[1];Jia, Jiantao^[1,2,3];Lai, Weiwei^[1,2,3];Xin, Xing^[1,2,3,4];Tang, Cane^[1];Luo, Dixian^[5];Tan, Tan^[5];Jiang, Yiqun^[1,2,3];Shi, Ying^[1,2,3,4];Liu, Yating^[1,2,3,4];Xiao, Desheng^[6];Chen, Ling^[1,2,3,4];Liu, Shao^[7];Mao, Chao^[1,2,3];Yin, Gang^[8];Cheng, Yan^[9];Fan, Jia(樊嘉)^[10,11]Cao, Ya^[1,2,3,4];Muegge, Kathrin^[12];Tao, Yongguang^[1,2,3,4];
语种：

English
期刊：

CANCER RESEARCH ISSN：0008-5472 2016 年 76 卷 19 期 (5743 - 5755) ; OCT
收录：
摘要：

Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT), which confers potent metastatic potential to cancer cells. Here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), a prevalent cancer in China. LSH expression was increased in NPC, where it was controlled by the Epstein-Barr virus-encoded protein LMP1. In NPC cells in vitro and in vivo, LSH promoted cancer progression in part by regulating expression of fumarate hydratase (FH), a core component of the tricarboxylic acid cycle. LSH bound to the FH promoter, recruiting the epigenetic silencer factor G9a to repress FH transcription. Clinically, we found that the concentration of TCA intermediates in NPC-patient sera was deregulated in the presence of LSH. RNAi-mediated silencing of FH mimicked LSH overexpression, establishing FH as downstream mediator of LSH effects. The TCA intermediates a-KG and citrate potentiated the malignant character of NPC cells, in part by altering IKK alpha-dependent EMT gene expression. In this manner, LSH furthered malignant progression of NPC by modifying cancer cell metabolism to support EMT. (C) 2016 AACR.
推荐引用方式
GB/T 7714：

He Xiaozhen,Yan Bin,Liu Shuang, et al. Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase [J].CANCER RESEARCH,2016,76(19):5743-5755.
APA：

He Xiaozhen,Yan Bin,Liu Shuang,Jia Jiantao,&Tao Yongguang.(2016).Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase .CANCER RESEARCH,76(19):5743-5755.
MLA：

He Xiaozhen, et al. "Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase" .CANCER RESEARCH 76,19(2016):5743-5755.

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