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Prevalence and Antimicrobial Resistance Patterns of Diarrheagenic Escherichia coli in Shanghai, China 期刊论文

编号：

4a006d75-801a-4feb-ba64-a306f116d4fd
作者：

Huang, Zheng^[1] Pan, Haijian^[2] Zhang, Pingping^[3] Cao, Xiaowei^[4] Ju, Wenting^[5] Wang, Chuanqing^[6] Zhang, Jianmin^[7] Meng, Jianghong^[8] Yuan, Zhengan^[9] Xu, Xuebin^[8,9]
语种：

English
期刊：

PEDIATRIC INFECTIOUS DISEASE JOURNAL ISSN：0891-3668 2016 年 35 卷 8 期 (835 - 839) ; AUG
收录：
关键词：

diarrheagenic Escherichia coli prevalence antibiotic resistance high-riskclone
摘要：

Background: Diarrheagenic Escherichia coli (DEC) is a major cause of bacterial gastroenteritis in children. Also, antibiotic resistance among DEC is becoming a critical area of concern in clinical settings. Methods: This study was conducted in 4 hospitals in Shanghai from June 2012 to October 2013. DEC isolates from stool samples of patients with diarrhea were examined to determine their antimicrobial susceptibilities and presence of virulence genes, in order to identify high risk clones. Results: A total of 735 (10.2%) DEC isolates were identified from 7204 stool samples from patients with diarrhea, including 374 enteropathogenic E. coli, 318 enterotoxigenic E. coli, 36 Shigella/enteroinvasive E. coli and 7 Shiga toxin-producing E. coli (STEC). Among the 735 DEC isolates, 299 (40.7%) were isolated from children less than 5 years old. High resistance rates were observed to streptomycin (90.7%), ampicillin (63.4%), nalidixic acid (61.1%), sulfisoxazole (49.1%), tetracycline (41.2%), trimethoprim (35.6%), trimethoprim-sulfamethoxazole (35.4%), followed by amoxicillin-clavulanic acid (27.2%), cefotaxime (24.5%), cefepime (23.5%), gentamicin (16.7%), ceftazidime (12.4%), chloramphenicol (10.6%), ciprofloxacin (7.2%) and ofloxacin (3.4%). All the isolates were susceptible to imipenem. In addition, potential virulence genes were screened by polymerase chain reaction. A total of 15 enterotoxigenic E. coli belonging to the same clone were identified to be associated with nosocomial neonatal diarrhea and resistant to greater than 10 antimicrobials. Conclusion: Our findings suggest that active surveillance programs combining both phenotypic and genetic data would help identify disease outbreaks and strengthen antibiotic management.
推荐引用方式
GB/T 7714：

Huang Zheng,Pan Haijian,Zhang Pingping, et al. Prevalence and Antimicrobial Resistance Patterns of Diarrheagenic Escherichia coli in Shanghai, China [J].PEDIATRIC INFECTIOUS DISEASE JOURNAL,2016,35(8):835-839.
APA：

Huang Zheng,Pan Haijian,Zhang Pingping,Cao Xiaowei,&Xu Xuebin.(2016).Prevalence and Antimicrobial Resistance Patterns of Diarrheagenic Escherichia coli in Shanghai, China .PEDIATRIC INFECTIOUS DISEASE JOURNAL,35(8):835-839.
MLA：

Huang Zheng, et al. "Prevalence and Antimicrobial Resistance Patterns of Diarrheagenic Escherichia coli in Shanghai, China" .PEDIATRIC INFECTIOUS DISEASE JOURNAL 35,8(2016):835-839.

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