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Downregulation of lipocalin-2 and Bim expression after remote limb preconditioning in the ischemic rat brain 期刊论文

编号：

4b4fe648-e957-47c7-bbf4-6df59a97c4e9
作者：

Liu, Mingli^[1];Chen, Jing^[1];Zhang, Shufan^[1];Ren, Chuancheng(任传成)*^[1]
语种：

English
期刊：

BRAIN RESEARCH ISSN：0006-8993 2018 年 1679 卷 (1 - 9) ; JAN 15
收录：
关键词：

Remote limb preconditioning Ischemic cerebral stroke Lipocain-2 Bim BOCT Neuronal death
摘要：

Although it has been proved that remote limb preconditioning (RPC) can exert neurological protection effects after ischemic cerebral stroke (ICS), the underlying mechanisms of RPC still need to be elucidated for its better transformation to clinical application. Lipocalin-2 (LCN2) was upregulated after cerebral ischemia and mediated reperfusion injury in the models of ischemic stroke. So here, we investigated that whether RPC could downregulate the levels of LCN2 protein and its receptor resulting from cerebral ischemia reperfusion (I/R) injury. The results showed that RPC could decrease the expression of LCN2 protein, but having no obvious effects on its receptor except the time point of 72 h after cerebral ischemia. Furthermore, we observed the downregulation of Bim after RPC in the course of ICS. (C) 2017 Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Liu Mingli,Chen Jing,Zhang Shufan, et al. Downregulation of lipocalin-2 and Bim expression after remote limb preconditioning in the ischemic rat brain [J].BRAIN RESEARCH,2018,1679:1-9.
APA：

Liu Mingli,Chen Jing,Zhang Shufan,Ren Chuancheng.(2018).Downregulation of lipocalin-2 and Bim expression after remote limb preconditioning in the ischemic rat brain .BRAIN RESEARCH,1679:1-9.
MLA：

Liu Mingli, et al. "Downregulation of lipocalin-2 and Bim expression after remote limb preconditioning in the ischemic rat brain" .BRAIN RESEARCH 1679(2018):1-9.

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