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SnWO4-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy 期刊论文 WOS高被引论文

编号：

4b654e78-b294-4a61-b664-62f757ea05c1
作者：

Zhang, Meng^[1,2];Cui, Zhaowen^[1];Song, Ruixue^[3];Lv, Bin^[4];Tang, Zhongmin^[1,2];Meng, Xianfu^[3];Chen, Xiaoyan^[3];Zheng, Xiangpeng^[4];Zhang, Jiawen(张家文)^[5]Yao, Zhenwei(姚振威)^[5]Bu, Wenbo^[1,3];
语种：

English
期刊：

BIOMATERIALS ISSN：0142-9612 2018 年 155 卷 (135 - 144) ; FEB
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关键词：

Tin tungstate Photodynamic therapy Efficiency Radiotherapy Tumor
摘要：

The "partial matching" between upconversion nanoparticle (UCNP) emission and absorption by photosensitizers (PSs) often leads to a theoretically reduced therapeutic efficiency in UC-based photodynamic therapy (PDT) strategies in which the chosen PSs have limited capabilities and are unable to utilize all the near-infrared-upconverted light. In this study, needle-like SnWO4 nanocrystals (SWs) with a broad UV-vis absorption region were synthesized to solve the problem. After covalent conjugation with UCNPs, all the UCNP-emitted light was effectively absorbed by SWs, triggering the type-I PDT process to activate ROS maxima. The unique nanostructure of the as-formed UCNP-SnWO4 nanohybrids (USWs) also enhanced the receiving light intensities of SW, which further boosted the antitumor efficacy. Meanwhile, the strong X-ray attenuation capacity of both tungsten and tin elements qualified the USWs as excellent radio-sensitizers for radiotherapy (RT) enhancement, which played a complementary role with PDT treatment because PDT-mediated induction arrested the cells in the G0-G1 cell cycle phase, and RT was more damaging toward cells in the G2/M phase. The remarkably enhanced UC-PDT/RT efficiency of USWs was next validated in vitro and in vivo, and the combined NIR light and ionizing irradiation treatment completely suppressed tumor growth, revealing its great potential as an efficient anticancer therapeutic agent against solid tumors. (C) 2017 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Zhang Meng,Cui Zhaowen,Song Ruixue, et al. SnWO4-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy [J].BIOMATERIALS,2018,155:135-144.
APA：

Zhang Meng,Cui Zhaowen,Song Ruixue,Lv Bin,&Bu Wenbo.(2018).SnWO4-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy .BIOMATERIALS,155:135-144.
MLA：

Zhang Meng, et al. "SnWO4-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy" .BIOMATERIALS 155(2018):135-144.

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