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NOTCH1 Signaling Regulates Self-Renewal and Platinum Chemoresistance of Cancer Stem-like Cells in Human Non-Small Cell Lung Cancer 期刊论文

编号：

4bd02bb2-446b-46b1-8217-387a2cbc4085
作者：

Zhang, Yun^[1,2];Xu, Wei^[1];Guo, Huiqin^[3];Zhang, Yanmei^[1];He, Yuexi^[1];Lee, Sau Har^[1];Song, Xin^[4];Li, Xiaoyan^[5];Guo, Yongqing^[6];Zhao, Yunlong^[3];Ding, Cheng^[3];Ning, Fei^[1];Ma, Yuanyuan^[7];Lei, QunYing(雷群英)^[8,9]Hu, Xiaoyu^[1];Li, Shengnan^[2];Guo, Wei^[1];
语种：

英文
期刊：

CANCER RESEARCH ISSN：0008-5472 2017 年 77 卷 11 期 (3082 - 3091) ; JUN 1
收录：
摘要：

Cancer stem-like cells (CSC) are thought to drive tumor initiation, metastasis, relapse, and therapeutic resistance, but their specific pathogenic characters in many cancers, including non-small cell lung cancer (NSCLC), have yet to be well defined. Here, we develop findings that the growth factor HGF promotes CSC sphere formation in NSCLC cell populations. In patient-derived sphere-forming assays (PD-SFA) with HGF, CD49f and CD104 were defined as novel markers of lung CSC (LCSC). In particular, we isolated a subpopulation of CD166(+)CD49f(hi)CD104(-)Lin(-) LCSC present in all human specimens of NSCLC examined, regardless of their histologic subtypes or genetic driver mutations. This specific cell population was tumorigenic and capable of self-renewal, giving rise to tumor spheres in vitro and orthotopic lung tumors in immune-compromised mice. Mechanistic investigations established that NOTCH1 was preferentially expressed in this cell subpopulation and required for self-renewal via the transcription factor HES1. Through a distinct HES1-independent pathway, NOTCH1 also protected LCSCs from cisplatin-induced cell death. Notably, treatment with a gamma-secretase inhibitor that blunts NOTCH1 function ablated self-renewing LCSC activity and restored platinum sensitivity in vitro and in vivo. Overall, our results define the pathogenic characters of a cancer stem-like subpopulation in lung cancer, the targeting of which may relieve platinum resistance in this disease. (C) 2017 AACR.
推荐引用方式
GB/T 7714：

Zhang Yun,Xu Wei,Guo Huiqin, et al. NOTCH1 Signaling Regulates Self-Renewal and Platinum Chemoresistance of Cancer Stem-like Cells in Human Non-Small Cell Lung Cancer [J].CANCER RESEARCH,2017,77(11):3082-3091.
APA：

Zhang Yun,Xu Wei,Guo Huiqin,Zhang Yanmei,&Guo Wei.(2017).NOTCH1 Signaling Regulates Self-Renewal and Platinum Chemoresistance of Cancer Stem-like Cells in Human Non-Small Cell Lung Cancer .CANCER RESEARCH,77(11):3082-3091.
MLA：

Zhang Yun, et al. "NOTCH1 Signaling Regulates Self-Renewal and Platinum Chemoresistance of Cancer Stem-like Cells in Human Non-Small Cell Lung Cancer" .CANCER RESEARCH 77,11(2017):3082-3091.

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