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Morbidity and Mortality of Laparoscopic Versus Open D2 Distal Gastrectomy for Advanced Gastric Cancer: A Randomized Controlled Trial 期刊论文 WOS高被引论文

编号：

4e524332-fbff-4f5c-8663-d0051cad20ba
作者：

Hu, Yanfeng^[1] Huang, Changming^[4] Sun, Yihong^[6] Su, Xiangqian^[9] Cao, Hui^[7] Hu, Jiankun^[10] Xue, Yingwei^[11] Suo, Jian^[12] Tao, Kaixiong^[13] He, Xianli^[14] Wei, Hongbo^[2] Ying, Mingang^[5] Hu, Weiguo^[7] Du, Xiaohui^[8] Chen, Pingyan^[3] Liu, Hao^[1] Zheng, Chaohui^[4] Liu, Fenglin^[6] Yu, Jiang^[1] Li, Ziyu^[9] Zhao, Gang^[7] Chen, Xinzu^[10] Wang, Kuan^[11] Li, Ping^[4] Xing, Jiadi^[9] Li, Guoxin^[1]
语种：

英文
期刊：

JOURNAL OF CLINICAL ONCOLOGY ISSN：0732-183X 2016 年 34 卷 12 期 (1350 - +) ; APR 20
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摘要：

Purpose
The safety and efficacy of radical laparoscopic distal gastrectomy (LG) with D2 lymphadenectomy for the treatment of advanced gastric cancer (AGC) remain controversial. We conducted a randomized controlled trial to compare laparoscopic and conventional open distal gastrectomy with D2 lymph node dissections for AGC.
Patients and Methods
Between September 2012 and December 2014, 1,056 patients with clinical stage T2-4aN0-3M0 gastric cancer were eligible for inclusion. They were randomly assigned to either the LG with D2 lymphadenectomy group (n = 528) or the open gastrectomy (OG) with D2 lymphadenectomy group (n = 528). Fifteen experienced surgeons from 14 institutions in China participated in the study. The morbidity and mortality within 30 days after surgery between the LG (n = 519) and the OG (n = 520) groups were compared on the basis of the modified intention-to-treat principle. Postoperative complications were stratified according to the Clavien-Dindo classification.
Results
The compliance rates of D2 lymphadenectomy were similar between the LG and OG groups (99.4% v 99.6%; P = .845). The postoperative morbidity was 15.2% in the LG group and 12.9% in OG group with no significant difference (difference, 2.3%; 95% CI, -1.9 to 6.6; P = .285). The mortality rate was 0.4% for the LG group and zero for the OG group (difference, 0.4%; 95% CI, -0.4 to 1.4; P = .249). The distribution of severity was similar between the two groups (P = .314).
Conclusion
Experienced surgeons can safely perform LG with D2 lymphadenectomy for AGC. (C) 2016 by American Society of Clinical Oncology
推荐引用方式
GB/T 7714：

Hu Yanfeng,Huang Changming,Sun Yihong, et al. Morbidity and Mortality of Laparoscopic Versus Open D2 Distal Gastrectomy for Advanced Gastric Cancer: A Randomized Controlled Trial [J].JOURNAL OF CLINICAL ONCOLOGY,2016,34(12):1350-+.
APA：

Hu Yanfeng,Huang Changming,Sun Yihong,Su Xiangqian,&Li Guoxin.(2016).Morbidity and Mortality of Laparoscopic Versus Open D2 Distal Gastrectomy for Advanced Gastric Cancer: A Randomized Controlled Trial .JOURNAL OF CLINICAL ONCOLOGY,34(12):1350-+.
MLA：

Hu Yanfeng, et al. "Morbidity and Mortality of Laparoscopic Versus Open D2 Distal Gastrectomy for Advanced Gastric Cancer: A Randomized Controlled Trial" .JOURNAL OF CLINICAL ONCOLOGY 34,12(2016):1350-+.

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