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Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons 期刊论文

编号：

4ee43a9c-94ea-4f2f-9cfe-c7d3a8a03d67
作者：

Huo, HaiQin^[1,2];Qu, ZhuangYin^[1,2];Yuan, Fang^[2];Ma, Lixiang(马丽香)^[3]Yao, Lin^[4];Xu, Min^[2];Hu, Yao^[1,2];Ji, Jing^[5];Bhattacharyya, Anita^[4,6];Zhang, SuChun^[4,6];Liu, Yan^[1,2];
语种：

English
期刊：

STEM CELL REPORTS ISSN：2213-6711 2018 年 10 卷 4 期 (1251 - 1266) ; APR 10
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摘要：

The brain of Down syndrome (DS) patients exhibits fewer interneurons in the cerebral cortex, but its underlying mechanism remains unknown. By morphometric analysis of cortical interneurons generated from DS and euploid induced pluripotent stem cells (iPSCs), we found that DS GABA neurons are smaller and with fewer neuronal processes. The proportion of calretinin over calbindin GABA neurons is reduced, and the neuronal migration capacity is decreased. Such phenotypes were replicated following transplantation of the DS GABAergic progenitors into the mouse medial septum. Gene expression profiling revealed altered cell migratory pathways, and correction of the PAK1 pathway mitigated the cell migration deficit in vitro. These results suggest that impaired migration of DS GABAergic neurons may contribute to the reduced number of interneurons in the cerebral cortex and hippocampus in DS patients.
推荐引用方式
GB/T 7714：

Huo Hai-Qin,Qu Zhuang-Yin,Yuan Fang, et al. Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons [J].STEM CELL REPORTS,2018,10(4):1251-1266.
APA：

Huo Hai-Qin,Qu Zhuang-Yin,Yuan Fang,Ma Lixiang,&Liu Yan.(2018).Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons .STEM CELL REPORTS,10(4):1251-1266.
MLA：

Huo Hai-Qin, et al. "Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons" .STEM CELL REPORTS 10,4(2018):1251-1266.

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