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Ubiquitin-Specific Protease 7 Accelerates p14(ARF) Degradation by Deubiquitinating Thyroid Hormone Receptor-Interacting Protein 12 and Promotes Hepatocellular Carcinoma Progression 期刊论文

编号：

4f6b3263-9121-4536-a8b1-14feb6b7fc29
作者：

Cai, JiaBin(蔡加彬)^[1,2]Shi, GuoMing^[1,2];Dong, ZhaoRu^[1,2];Ke, AiWu^[1,2];Ma, HongHui^[3];Gao, Qiang(高强)^[1,2]Shen, ZaoZhuo^[1,2];Huang, XiaoYong(黄晓勇)^[1,2]Chen, Hao^[3];Yu, DingDang^[3];Liu, LiXin^[1,2];Zhang, PengFei^[1,2];Zhang, Chi^[1,2];Hu, MeiYu^[1,2];Yang, LiuXiao^[1,2];Shi, YingHong(史颖弘)^[1,2]Wang, XiaoYing^[1,2];Ding, ZhenBin(丁振斌)^[1,2]Qiu, ShuangJian(邱双健)^[1,2]Sun, HuiChuan(孙惠川)^[1,2]Zhou, Jian(周俭)^[1,2,3,4]Shi, Yujiang G.^[3,5];Fan, Jia(樊嘉)*^[1,2,4]
语种：

English
期刊：

HEPATOLOGY ISSN：0270-9139 2015 年 61 卷 5 期 (1603 - 1614) ; MAY
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摘要：

The prognosis for hepatocellular carcinoma (HCC) remains dismal in terms of overall survival (OS), and its molecular pathogenesis has not been completely defined. Here, we report that expression of deubiquitylase ubiquitin-specific protease 7 (USP7) is higher in human HCC tissues than in matched peritumoral tissues. Ectopic USP7 expression promotes growth of HCC cells in vivo and in vitro. Mechanistically, USP7 overexpression fosters HCC cell growth by forming a complex with and stabilizing thyroid hormone receptor-interacting protein 12 (TRIP12), which induces constitutive p14(ARF) ubiquitination. Clinically, USP7 overexpression is significantly correlated with a malignant phenotype, including larger tumor size, multiple tumor, poor differentiation, elevated alpha-fetoprotein, and microvascular invasion. Moreover, overexpression of USP7 and/or TRIP12 correlates with shorter OS and higher cumulative recurrence rates of HCC. Conclusion: USP7 stabilizes TRIP12 by deubiquitination, thus constitutively inactivating p14(ARF) and promoting HCC progression. This represents a novel marker for predicting prognosis and a potential therapeutic target for HCC. (Hepatology 2015;61:1603-1614)
推荐引用方式
GB/T 7714：

Cai Jia-Bin,Shi Guo-Ming,Dong Zhao-Ru, et al. Ubiquitin-Specific Protease 7 Accelerates p14(ARF) Degradation by Deubiquitinating Thyroid Hormone Receptor-Interacting Protein 12 and Promotes Hepatocellular Carcinoma Progression [J].HEPATOLOGY,2015,61(5):1603-1614.
APA：

Cai Jia-Bin,Shi Guo-Ming,Dong Zhao-Ru,Ke Ai-Wu,&Fan Jia.(2015).Ubiquitin-Specific Protease 7 Accelerates p14(ARF) Degradation by Deubiquitinating Thyroid Hormone Receptor-Interacting Protein 12 and Promotes Hepatocellular Carcinoma Progression .HEPATOLOGY,61(5):1603-1614.
MLA：

Cai Jia-Bin, et al. "Ubiquitin-Specific Protease 7 Accelerates p14(ARF) Degradation by Deubiquitinating Thyroid Hormone Receptor-Interacting Protein 12 and Promotes Hepatocellular Carcinoma Progression" .HEPATOLOGY 61,5(2015):1603-1614.

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