首页 / 院系成果 / 成果详情页

Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue 期刊论文

编号：

4f816828-a941-4c5a-9eb1-3583f274c73f
作者：

Wan, ZhengYong^[1] Yao, Jin^[1] Mao, TianQi^[1,2] Wang, XinLong^[1] Wang, HaiFeng^[1] Chen, WenXue^[1] Yin, Hong^[1] Chen, FenEr^[1,2] De Clercq, Erik^[3] Daelemans, Dirk^[3] Pannecouque, Christophe^[3]
语种：

English
期刊：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ISSN：0223-5234 2015 年 102 卷 (215 - 222) ; SEP 18
收录：
关键词：

Antiviral agent Biological activity Highly conserved residue Molecular hybridization Molecular simulation
摘要：

Based on molecular simulation, the etravirine-VRX-480773 hybrids previously disclosed by our group were optimized to yield novel pyrimidine sulfonylacetanilides 8 with improved activity against a panel of seven clinically relevant single and double mutant strains of HIV-1. The improvement in potency in this in vitro model of HIV RNA replication partly validates the mechanism by which this class of allosteric pyrimidine derivatives inhibits the reverse transcriptase (RT), and represents a remarkable step forward in the development of anti-HIV drugs. (C) 2015 Elsevier Masson SAS. All rights reserved.
推荐引用方式
GB/T 7714：

Wan Zheng-Yong,Yao Jin,Mao Tian-Qi, et al. Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue [J].EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2015,102:215-222.
APA：

Wan Zheng-Yong,Yao Jin,Mao Tian-Qi,Wang Xin-Long,&Pannecouque Christophe.(2015).Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue .EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,102:215-222.
MLA：

Wan Zheng-Yong, et al. "Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue" .EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 102(2015):215-222.

浏览次数：5  下载次数：0

分享到：

浏览次数：5

下载次数：0

打印次数：0