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Lipocalin 2 over-expression facilitates progress of castration-resistant prostate cancer via improving androgen receptor transcriptional activity 期刊论文

编号：

4f9ab8f3-bd3e-4600-8e73-edafdd51b152
作者：

Ding, Guanxiong^[1];Wang, Jianqing^[1];Feng, Chenchen(冯陈陈)^[1]Jiang, Haowen(姜昊文)^[1]Xu, Jianfeng^[1,2];Ding, Qiang(丁强)^[1]
语种：

English
期刊：

ONCOTARGET ISSN：1949-2553 2016 年 7 卷 39 期 (64309 - 64317) ; SEP 27
收录：
关键词：

castration-resistant prostate cancer lipocalin 2 androgen receptor cell proliferation transcriptional activity
摘要：

Background: Castration-resistant prostate cancer (CRPC) is the lethal phenotype of prostate cancer. Lipocalin 2 (LCN2) is aberrantly expressed in many cancers including primary prostate cancer (PCa), but its role in CRPC has not been reported. Results: LCN2 expression was upregulated in human primary PCa and CRPC tissues. Overexpression of LCN2 promoted C4-2B and 22RV1 cell proliferation while knockdown of LCN2 markedly inhibited C4-2B and 22RV1 cell growth. LCN2 overexpression led to increased AR downstream gene SLC45A3 without upregulating AR expression. In the xenograft model, overexpression of LCN2 significantly promoted tumor growth. Methods: LCN2 expression was detected in primary PCa and CRPC tissues and cell lines C4-2B and 22RV1 using immunohistochemistry and western blotting, respectively. Serum LCN2 level was detected vi ELISA. Lentiviruses-mediated over-expression of LCN2 and LCN2 knockdown were performed in CRPC cell lines. Expressions of androgen receptor(AR) downstream genes was examined in cell lines, in CRPC tissues, and in animal models. Conclusion: LCN2 could facilitate cell proliferation of CRPC via AR transcriptional activity. LCN2 could be a novel target in CRPC.
推荐引用方式
GB/T 7714：

Ding Guanxiong,Wang Jianqing,Feng Chenchen, et al. Lipocalin 2 over-expression facilitates progress of castration-resistant prostate cancer via improving androgen receptor transcriptional activity [J].ONCOTARGET,2016,7(39):64309-64317.
APA：

Ding Guanxiong,Wang Jianqing,Feng Chenchen,Jiang Haowen,&Ding Qiang.(2016).Lipocalin 2 over-expression facilitates progress of castration-resistant prostate cancer via improving androgen receptor transcriptional activity .ONCOTARGET,7(39):64309-64317.
MLA：

Ding Guanxiong, et al. "Lipocalin 2 over-expression facilitates progress of castration-resistant prostate cancer via improving androgen receptor transcriptional activity" .ONCOTARGET 7,39(2016):64309-64317.

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