Objectives: It was well known that the utilizations of antiepileptic drugs had been shown in many countries, such as Italy, Netherlands, Dutch and so on. However, those in China were rarely disappeared. In this study, the AEDs using pattern in clinic for children at Shanghai of China were studied. Moreover, the application of monotherapy and polytherapy of AEDs was analyzed to assess whether drug mono and polytherapy are rational or not. Methods: In this study, 8160 prescriptions of total 1,483,061 children aged 0-18 years in the Children's Hospital of Fudan university on the diagnosis of epilepsy were retrieved from July, 2014 to October, 2015. Prescribing pattern of AEDs and the individual AEDs applied to monotherapy and polytherapy on using rate and dosage were analyzed. Besides, the utilization of valproic acid (VPA), levetiracetam (LEV) and topiramate (TPM) prescribed to different ages of children were covered. Results: Children aged from 2-11 years were the most frequency in the prescriptions with 74.07%. The VPA solution, LEV tablet, oxcarbazepine ( OX) tablet and TPM were in the highest frequency used both in monotherapy and polytherapy. Meanwhile, proportion of older and newer AEDs on polytherapy arrived at 59.83 and 53.84%, which was higher than those of monotherapy with 18.67 and 39.63%. Furthermore, the dosage was increased from 9.50 +/- 0.17 to 11.49 +/- 0.34 mL in VPA group, from 4.79 +/- 0.1 to 5.61 +/- 0.19 mL in LEV group and from 59.45 +/- 2.46 to 77.34 +/- 3.06 mg in TPM with the number of medication added on polytherapy, which were significantly higher than monotherapy. Conclusion: The usage of newer AEDs in children was all-too-frequency at Shanghai of China, while polytherapy was most commonly used in Chinese children and certain different dose between monotherapy and polytherapy was found in VPA, LEV and TPM.
[1]Fudan Univ, Childrens Hosp, Dept Pharm, 399 Wanyuan Rd, Shanghai 201102, Peoples R China.
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