首页 / 院系成果 / 成果详情页

Prior exposure to enriched environment reduces nitric oxide synthase after transient MCAO in rats 期刊论文

编号：

508f49d5-84ee-4ca1-bebf-cf5bc9564950
作者：

Yu, Kewei(余克威)#^[1,2]Wu, Yi(吴毅)*^[1,2,3,4]Hu, Yongshan(胡永善)^[1,2,4]Zhang, Qi^[1,2];Xie, Hongyu(谢鸿宇)^[1,2]Liu, Gang(刘罡)^[1,3]Chen, Yao^[3];Guo, Zhenzhen(郭真真)^[1,2]Jia, Jie(贾杰)^[1,2,4]
语种：

English
期刊：

NEUROTOXICOLOGY ISSN：0161-813X 2013 年 39 卷 (146 - 152) ; DEC
收录：
关键词：

Enriched environment Ischemia iNOS nNOS
摘要：

Increasing evidence shows that exposure to an enriched environment (EE) after cerebral ischemia/reperfusion injury is neuroprotective in animal models. However, little is known about of the neuroprotective effects of EE exposure prior to injury. The current study examined the effects of prior EE exposure on inducible and neuronal nitric oxide syntheses (iNOS and nNOS) after transient middle cerebral artery occlusion (tMCAO) in rats. A total of 72 rats were exposed to EE or standard housing condition (SC) for 1 month, followed by 90-min MCAO and reperfusion or sham surgery, leading to the following three groups: (1) EE + MCAO (n = 24), (2) SC + MCAO (n = 24), (3) SC + sham (n = 24). Rats were sacrificed at 1, 6, or 24 h after MCAO (n = 6/group) for iNOS and nNOS mRNA quantification by real-time PCR and at 24 h after MCAO (n = 6/group) for iNOS and nNOS protein quantification by Western blot or were evaluated for neurological function outcomes, then sacrificed to assess infarct volume (n = 6/group). Results showed that prior exposure to EE reduced iNOS and nNOS mRNA and protein and improved neurological status after MCAO without affecting infarct volume, suggesting that EE may provide neuroprotection via ischemic preconditioning. (C) 2013 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Yu Kewei,Wu Yi,Hu Yongshan, et al. Prior exposure to enriched environment reduces nitric oxide synthase after transient MCAO in rats [J].NEUROTOXICOLOGY,2013,39:146-152.
APA：

Yu Kewei,Wu Yi,Hu Yongshan,Zhang Qi,&Jia Jie.(2013).Prior exposure to enriched environment reduces nitric oxide synthase after transient MCAO in rats .NEUROTOXICOLOGY,39:146-152.
MLA：

Yu Kewei, et al. "Prior exposure to enriched environment reduces nitric oxide synthase after transient MCAO in rats" .NEUROTOXICOLOGY 39(2013):146-152.

浏览次数：4  下载次数：0

分享到：

浏览次数：4

下载次数：0

打印次数：0