MicroRNAs (miRNAs) are dysregulated in cancers, including human non-small cell lung cancer (NSCLC). The function of MicroRNA-107-5p (miR-107-5p) in NSCLC is not fully elucidated. Epidermal growth factor receptor (EGFR) is a cancer-driven gene in tumorigenesis. In this study, we found that miR-107-5p was significantly decreased in NSCLC tissues and NSCLC cell lines. Moreover, our results indicated that miR-107-5p could suppress cell proliferation, inhibit metastasis, impede cell cycle, and promote apoptosis via directly targeting EGFR. We also investigated roles of miR-107-5p in vivo. The results showed that it could inhibit tumor growth. Therefore, our study demonstrated that miR-107-5p not only suppressed the progression in NSCLC cells by inhibiting the expression of EGFR, but also could be a promising and a new potential therapeutic target for lung cancer.
[1]Shanghai Univ, Sch Life Sci, Lab Noncoding RNA & Canc, Shanghai, Peoples R China;
[2]Fudan Univ, Shanghai Canc Ctr, Canc Inst, Dept Oncol,Shanghai Med Coll, Shanghai, Peoples R China;
[3]Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Pulm Med, Shanghai, Peoples R China
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