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Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma: a meta-analysis 期刊论文

编号：

527f4c76-88fb-48b5-8d28-321e9fdbd3dc
作者：

Yang, Zongguo(杨宗国)#*^[1]Zhuang, Liping^[2,3];Lu, Yunfei(陆云飞)^[1]Xu, Qingnian(徐庆年)^[1]Tang, Bozong(汤伯宗)^[1]Chen, Xiaorong(陈晓蓉)*^[1]
语种：

English
期刊：

ONCOTARGET ISSN：1949-2553 2016 年 7 卷 11 期 (12525 - 12536) ; MAR 15
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关键词：

hepatitis B virus X protein hepatocellular carcinoma basal core promoter mutation A1762T/G1764A
摘要：

Basal core promoter (BCP) A1762T/G1764A dual mutations in hepatocarcinogenesis remain controversial. Published studies up to June 1, 2015 investigating the frequency of A1762T/G1764A dual mutations from chronic hepatitis B virus (HBV) infection, including hepatocellular carcinoma (HCC), were systematically identified. A total of 10,240 patients with chronic HBV infection, including 3729 HCC cases, were included in 52 identified studies. HCC patients had a higher frequency of BCP A1762T/G1764A dual mutations compared with asymptomatic HBsAg carriers (ASC) and patients with chronic hepatitis B (CHB) and liver cirrhosis (LC) (OR = 5.59, P < 0.00001; OR = 2.87, P < 0.00001; OR = 1.55, P = 0.02, respectively). No statistically significant difference was observed in the frequency of A1762T/G1764A dual mutations in cirrhotic HCC versus non-cirrhotic HCC patients (OR = 2.06, P = 0.05). Chronic HBV-infected patients and HCC patients with genotype B had a significantly lower risk of A1762T/G1764A dual mutations compared with patients with genotype C (OR = 0.30, P < 0.0001 and OR = 0.34, P = 0.04, respectively). In HBV genotype C subjects, A1762T/G1764A dual mutations contributed to significantly higher risk for HCC developing compared with non-mutation ones (OR = 3.47, P < 0.00001). In conclusion, A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma, particularly in an HBV genotype C population, even without progression to cirrhosis.
推荐引用方式
GB/T 7714：

Yang Zongguo,Zhuang Liping,Lu Yunfei, et al. Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma: a meta-analysis [J].ONCOTARGET,2016,7(11):12525-12536.
APA：

Yang Zongguo,Zhuang Liping,Lu Yunfei,Xu Qingnian,&Chen Xiaorong.(2016).Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma: a meta-analysis .ONCOTARGET,7(11):12525-12536.
MLA：

Yang Zongguo, et al. "Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma: a meta-analysis" .ONCOTARGET 7,11(2016):12525-12536.

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