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Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene 期刊论文

编号：

5294cafa-09a0-4d36-9979-2daa0e85a953
作者：

Wang, Qiaoqiao^[1];Li, Jiyu^[1];Yang, Xinmiao^[2];Sun, Hefen^[1];Gao, Shuiping^[1];Zhu, Hua^[3];Wu, Jiong^[1];Jin, Wei(金伟)*^[1]
语种：

English
期刊：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA ISSN：1672-9145 2013 年 45 卷 3 期 (179 - 187) ; MAR
收录：
关键词：

Nrf2 BRCA1 promoter histone acetylation breast cancer
摘要：

BRCA1 is closely related to the pathogenesis of breast cancer. The activity of BRCA1 promoter is regulated by transcriptional factors. The transcription factor Nrf2 (Nuclear factor-erythroid-2p45-related factor 2) is a potent transcriptional activator and plays a central role in inducible expression of many cytoprotective genes. In this report, we found that over-expression of Nrf2 stimulated BRCA1 expression, knockdown of Nrf2 attenuated BRCA1 expression. Nrf2 also interacted with CBP and p300 to form an active transcription complex, which could bind to the ARE (antioxidant response element) site on the BRCA1 promoter and activate its transcription by inducing histone acetylation. Our finding could lead to a better understanding of the development of breast cancer.
推荐引用方式
GB/T 7714：

Wang Qiaoqiao,Li Jiyu,Yang Xinmiao, et al. Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene [J].ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2013,45(3):179-187.
APA：

Wang Qiaoqiao,Li Jiyu,Yang Xinmiao,Sun Hefen,&Jin Wei.(2013).Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene .ACTA BIOCHIMICA ET BIOPHYSICA SINICA,45(3):179-187.
MLA：

Wang Qiaoqiao, et al. "Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene" .ACTA BIOCHIMICA ET BIOPHYSICA SINICA 45,3(2013):179-187.

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