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The Analysis of Risk Factors and Survival Outcome for Chinese Patients with Epilepsy with High-Grade Glioma 期刊论文

编号：

542a5aef-f9f4-4af8-ada4-de5f55a6a908
作者：

Yu, Zhengda#^[1]Zhang, Nan(张南)#^[1]Hameed, N. U. Farrukh^[1];Qiu, Tianming(邱天明)^[1]Zhuang, Dongxiao(庄冬晓)^[1]Lu, Junfeng(路俊锋)^[1]Wu, Jinsong(吴劲松)*^[1]
语种：

英文
期刊：

WORLD NEUROSURGERY ISSN：1878-8750 2019 年 125 卷 (E947 - E957) ; MAY
收录：
关键词：

Epilepsy Function Glioma Survival
摘要：

OBJECTIVE: To evaluate the risk factors of tumor-related epilepsy (TRE) and the relationship between TRE and functional/survival outcomes in patients with high-grade glioma (HGG).
METHODS: The clinical data of 587 patients with HGG were retrospectively analyzed. A chi(2) test and logistic multiple-regression analysis were used to analyze factors associated with TRE. Logistic and Cox regression were used to analyze factors that may influence functional and survival outcomes.
RESULTS: Glioma location in temporal (odds ratio [OR], 0.439; P = 0.04) and parietal lobes (OR, 0.092; P = 0.02) were independent protective factors of preoperative epilepsy, compared with gliomas of frontal lobe. Preoperative epilepsy (OR, 9.290; P < 0.001) and dominant hemispheric location (OR, 2.616; P = 0.04) were independent risk factors of postoperative epilepsy. On univariate analysis, patients with preoperative epilepsy had longer progression-free survival (PFS) (P = 0.001) and overall survival (OS) (P < 0.001). Multivariate analysis further confirmed that preoperative epilepsy was an independent protective factor of OS (hazard ratio, 0.587; P = 0.008).
CONCLUSIONS: In patients with HGG, preoperative epilepsy is significantly associated with tumor involvement of the frontal lobe, whereas postoperative epilepsy is associated with preoperative epilepsy and dominant hemispheric location. Also, patients with HGG with preoperative epilepsy have better PFS and OS.
推荐引用方式
GB/T 7714：

Yu Zhengda,Zhang Nan,Hameed N. U. Farrukh, et al. The Analysis of Risk Factors and Survival Outcome for Chinese Patients with Epilepsy with High-Grade Glioma [J].WORLD NEUROSURGERY,2019,125:E947-E957.
APA：

Yu Zhengda,Zhang Nan,Hameed N. U. Farrukh,Qiu Tianming,&Wu Jinsong.(2019).The Analysis of Risk Factors and Survival Outcome for Chinese Patients with Epilepsy with High-Grade Glioma .WORLD NEUROSURGERY,125:E947-E957.
MLA：

Yu Zhengda, et al. "The Analysis of Risk Factors and Survival Outcome for Chinese Patients with Epilepsy with High-Grade Glioma" .WORLD NEUROSURGERY 125(2019):E947-E957.
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