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Molecular epidemiology of Cryptococcus neoformans species complex isolates from HIV-positive and HIV-negative patients in southeast China 期刊论文

编号：

543dd02a-8912-4410-a30c-09edabd16616
作者：

Chen, Min[0]^[1] Li, Xiaoran[1]^[2] Wu, Shaoxi[2]^[3] Tang, Xiaoping[3]^[4] Feng, Biwei[4]^[5] Yao, Zhirong[5]^[6] Pan, Weihua[6]^[7] Liao, Wanqing[7]^[7] Quan, Zhexue[8]^[8]
地址：

[1]Peking University, Department of Medicine,Beijing,China
[2]Washington University in St. Louis, Department of Biomedical Engineering,St Louis,United States
[3]Chinese Academy of Medical Sciences, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs,Beijing,China
[4]Jinan University, Department of Infectious Diseases,Guangzhou,China
[5]Fudan University, Institute of Genetics,Shanghai,China
[6]Shanghai Jiao Tong University School of Medicine, Department of Dermatology,Shanghai,China
[7]Changzheng Hospital, Department of Dermatology,Shanghai,China
[8]Fudan University, Department of Microbiology and Microbial Engineering,Shanghai,China
语种：

英文
期刊：

Frontiers of Medicine in China ISSN：1673-7342 2010 年 4 卷 1 期 (117 - 126)
收录：
关键词：

Cryptococcosis Cryptococcus gattii Cryptococcus neoformans Mating type Molecular epidemiology Molecular type
摘要：

This study investigated the molecular types of the Cryptococcus neoformans species complex isolates and their clinical manifestations among human immunodeficiency virus (HIV)-positive and HIV-negative patients in southeast China in the past 15 years. The molecular types of 109 isolates from 108 patients were analyzed by the PCR fingerprinting method, sequences of internal transcribed spacers of rDNA (ITS region), and sequences of the capsule-associated gene (CAP59). In HIV-positive patients, clinical isolates were grouped into molecular types VNI (75%, 15/20), VNII (15%, 3/20), and VNIII (10%, 2/20). In HIV-negative patients, the majority of the clinical isolates were grouped into molecular types VNI (72%, 64/89), VNII (13%, 12/89), VGI (12%, 11/89), VNIII (1%, 1/89), and VGII (1%, 1/89). In reference to the mating type of the isolates, 97% (106/109) were of the MATα, 2% (2/109) were of the MATα/- and 1% (1/109) were of the MATα/a. As for the clinical manifestations of the molecular types among the patients, the average cerebrospinal fluid (CSF) pressure of the patients infected by the C. gattii was higher than that of the patients infected by the C. neoformans. These results suggest that both HIV-positive and HIV-negative cryptococcal patients in the southeast of China are mostly infected by the C. neoformans strains. No C. gattii strains were found in HIV-positive patients. © 2010 Higher Education Press and Springer Berlin Heidelberg.
推荐引用方式
GB/T 7714：

Chen Min/7406353413[0],Li Xiaoran/15757295400[1],Wu Shaoxi/8422808200[2], et al. Molecular epidemiology of Cryptococcus neoformans species complex isolates from HIV-positive and HIV-negative patients in southeast China [J].Frontiers of Medicine in China,2010,4(1):117-126.
APA：

Chen Min/7406353413[0],Li Xiaoran/15757295400[1],Wu Shaoxi/8422808200[2],Tang Xiaoping/8442040100[3],&Quan Zhexue/13003353800[8].(2010).Molecular epidemiology of Cryptococcus neoformans species complex isolates from HIV-positive and HIV-negative patients in southeast China .Frontiers of Medicine in China,4(1):117-126.
MLA：

Chen Min/7406353413[0], et al. "Molecular epidemiology of Cryptococcus neoformans species complex isolates from HIV-positive and HIV-negative patients in southeast China" .Frontiers of Medicine in China 4,1(2010):117-126.

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