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Effects of electrophysiological heterogeneity on vulnerability to re-entry in human ventricular tissue: A simulation study 会议论文

编号：

54834cd6-7ebb-445f-a520-ce6de083aee0
作者：

Song, Biao ; Jin, Lian ; Wang, Jianfei ; Qian, Li ; Wu, Xiaomei (1, 2, 3)
作者单位：

(1) Department of Electronic Engineering, Fudan University1, Shanghai; CO; 200433, China (2) Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention (MICCAI) of Shanghai, Fudan University, China (3) Shanghai Engineering Research Center of Assistive Devices, China
会议名称：

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
会议时间：
会议地点：

Jeju Island, Korea, Republic of
出版信息：

2017 年 (1274 - 1277)
摘要：

In this study, we constructed a two-dimensional ventricular tissue sheet with cellular electrophysiology modified from the Ten Tusscher 2006 Model. Heterogeneity was created by dividing the tissue into endocardium, midmyocardium and epicardium, further enhanced by a central ischemic zone. Subsequently, we investigated how electrophysiological heterogeneity affects re-entry initiation and maintenance in this tissue. Furthermore, we analyzed the vulnerable window (VW) under several conditions and concluded that heterogeneity across various myocardia expands the VW further than the monolayer myocardium model does. © 2017 IEEE.
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