首页 / 院系成果 / 成果详情页

Synergistic effects of c-Jun and SP1 in the promotion of TGF beta 1-mediated diabetic nephropathy progression 期刊论文

编号：

552a7587-752f-4519-aaf6-8b97d1da5782
作者：

Gao, Pan(高攀)#^[1,2]Wei, Yingze^[1];Zhang, Zhigang(张志刚)^[1]Zeng, Wenjiao(曾文姣)^[1]Sun, Daming^[3];Liu, Danyang^[1];Hou, Bo^[1];Zhang, Congying^[1];Zhang, Nong(张农)^[1]Li, Hui(李慧)*^[1]Li, Liliang(李立亮)*^[4]
语种：

英文
期刊：

EXPERIMENTAL AND MOLECULAR PATHOLOGY ISSN：0014-4800 2016 年 100 卷 3 期 (441 - 450) ; JUN
收录：
关键词：

c-Jun SP1 TGF beta 1 Synergy Phosphorylation Diabetic nephropathy
摘要：

Diabetic nephropathy (DN) is a major complication of diabetes mellitus. Transforming growth factor beta 1 (TGF beta 1) is a well-distinguished mediator of progressive renal fibrosis in DN. However, the molecular mechanisms contributing to enhanced TGF beta 1 expression in the progression of DN are not fully understood. Herein, we reported that c-Jun and specificity protein 1 (SP1) were critical upstream regulators of TGF beta 1 expression in DN. The increase in c-Jun and SP1 expressions was positively correlated with TGF beta 1 in both high glucose treated human renal mesangial cells (HRMCs) and diabetic kidneys. Furthermore, c-Jun dose-dependently promoted SP1-mediated TGF beta 1 transcription and vice versa. The synergistic effects of c-Jun and SP1 were attributed to their auto-regulation and cross-activation. Moreover, enhanced phosphorylation levels of c-Jun and SP1 were accompanied with increased TGF beta 1 expression in diabetic kidneys. Accordingly, dephosphorylation of c-Jun and SP1 by the specific c-Jun N-terminal kinase (JNK) inhibitor SP600125 prevented the increase in TGF beta 1 expression. These results suggested that c-Jun and SP1 synergistically activated profibrotic TGF beta 1 expression in the development of DN by auto-regulation, cross-activation and phospho-modification. (C) 2016 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Gao Pan,Wei Yingze,Zhang Zhigang, et al. Synergistic effects of c-Jun and SP1 in the promotion of TGF beta 1-mediated diabetic nephropathy progression [J].EXPERIMENTAL AND MOLECULAR PATHOLOGY,2016,100(3):441-450.
APA：

Gao Pan,Wei Yingze,Zhang Zhigang,Zeng Wenjiao,&Li Liliang.(2016).Synergistic effects of c-Jun and SP1 in the promotion of TGF beta 1-mediated diabetic nephropathy progression .EXPERIMENTAL AND MOLECULAR PATHOLOGY,100(3):441-450.
MLA：

Gao Pan, et al. "Synergistic effects of c-Jun and SP1 in the promotion of TGF beta 1-mediated diabetic nephropathy progression" .EXPERIMENTAL AND MOLECULAR PATHOLOGY 100,3(2016):441-450.

浏览次数：2  下载次数：0

分享到：

浏览次数：2

下载次数：0

打印次数：0