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Long-term outcomes and prognostic analysis of radiofrequency ablation for small hepatocellular carcinoma: 10-year follow-up in Chinese patients 期刊论文

编号：

552ef3ac-6b2e-456b-ad3e-6af7f942af98
作者：

Zhang, Lan(张岚)#^[1,2]Ge, NingLin^[1,2];Chen, Yi(陈漪)^[1,2]Xie, XiaoYing^[1,2];Yin, Xin(殷欣)^[1,2]Gan, YuHong(干育红)^[1,2]Zhang, BoHeng(张博恒)^[1,2]Zhang, JuBo^[1,2];Chen, RongXin(陈荣新)^[1,2]Wang, YanHong(王艳红)^[1,2]Ye, ShengLong(叶胜龙)^[1,2]Ren, ZhengGang(任正刚)*^[1,2]
语种：

English
期刊：

MEDICAL ONCOLOGY ISSN：1357-0560 2015 年 32 卷 3 期 ; MAR
收录：
关键词：

Hepatocellular carcinoma Radiofrequency ablation Prognosis factors Long-term survival
摘要：

Radiofrequency ablation (RFA) has been used as a curative therapy for small hepatocellular carcinoma (HCC). However, relatively little is known about the long-term outcome of RFA for small HCC in a background of hepatitis B infection, which is common among the Chinese population. Between May 2001 and May 2012, 837 patients with HCC nodules <= 3 cm treated with RFA were enrolled in this study. We evaluated long-term survival rates, local tumor progression rates, complications and the prognostic factors. Among 1020 tumor nodules in 837 patients, complete ablation was achieved in 98.8 % (1008/1020) and the 1-, 3-, 5-, and 10-year overall survival rates were 91, 71, 54, and 33 %, respectively. Multivariate analysis revealed that tumor number [P = 0.003, hazard ratio (HR) 1.523, 95 % confidence interval (CI) 1.158-2.004], Child-Pugh grade (P = 0.001, HR 3.089, 95 % CI 2.238-4.266), and serum-glutamyltranspeptidase level (P = 0.002, HR 1.576, 95 % CI 1.251-1.985) were independent predictors of overall survival. The 1-, 3-, 5-, and 10-year recurrence-free survival rates were 74, 44, 30, and 15 %, respectively. Multivariate analysis revealed that serum a-fetoprotein level (P = 0.041, HR 1.249, 95 % CI 1.028-1.517) and tumor number (P = 0002, HR 1.449, 95 % CI 1.143-1.836) were independent predictors of recurrence-free survival. There were no procedure-related patient deaths and major complications occurred in 0.59 % (5/837) of patients. RFA achieved comparable long-term overall survival rates to those of surgical resection with fewer major complications and could therefore be considered as an alternative option for curative treatment of patients with small liver cancer.
推荐引用方式
GB/T 7714：

Zhang Lan,Ge Ning-Lin,Chen Yi, et al. Long-term outcomes and prognostic analysis of radiofrequency ablation for small hepatocellular carcinoma: 10-year follow-up in Chinese patients [J].MEDICAL ONCOLOGY,2015,32(3).
APA：

Zhang Lan,Ge Ning-Lin,Chen Yi,Xie Xiao-Ying,&Ren Zheng-Gang.(2015).Long-term outcomes and prognostic analysis of radiofrequency ablation for small hepatocellular carcinoma: 10-year follow-up in Chinese patients .MEDICAL ONCOLOGY,32(3).
MLA：

Zhang Lan, et al. "Long-term outcomes and prognostic analysis of radiofrequency ablation for small hepatocellular carcinoma: 10-year follow-up in Chinese patients" .MEDICAL ONCOLOGY 32,3(2015).

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