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Design, synthesis and phenotypic evaluation of N-biaryl amides for IL-17A suppression 期刊论文

编号：

560112f7-98e7-423a-bbba-42626e9b1ea1
作者：

Qiu, Ruomeng^[1];Shi, Wenli^[2];Cai, Ting^[2];Pei, Siyu^[2];Tang, Ting^[1];Huang, Yafei^[1];Wang, Huan^[1];Shao, Liming^[1];Qiu, Ju^[2];Wang, Yonghui(王永辉)*^[1]
地址：

[1]Fudan Univ, Sch Pharm, Dept Med Chem, 826 Zhangheng Rd, Shanghai 201203, Peoples R China;
[2]Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China
语种：

English
期刊：

MEDCHEMCOMM ISSN：2040-2503 2016 年 7 卷 12 期 (2344 - 2348)
收录：
摘要：

A series of N-biaryl amides for Th17 cell phenotypic screening were designed and quickly prepared by microwave-assisted solid-phase organic synthesis. The structure-activity relationship of the three regions of the amides was explored and potent small molecular inhibitors that suppress IL-17A production in mouse Th17 cells were identified. Compound 6h showed excellent suppression of IL-17A with an IC50 of 13 nM, which can be employed as a chemical tool for target identification and Th17 cell-related biological studies.
推荐引用方式
GB/T 7714：

Qiu Ruomeng,Shi Wenli,Cai Ting, et al. Design, synthesis and phenotypic evaluation of N-biaryl amides for IL-17A suppression [J].MEDCHEMCOMM,2016,7(12):2344-2348.
APA：

Qiu Ruomeng,Shi Wenli,Cai Ting,Pei Siyu,&Wang Yonghui.(2016).Design, synthesis and phenotypic evaluation of N-biaryl amides for IL-17A suppression .MEDCHEMCOMM,7(12):2344-2348.
MLA：

Qiu Ruomeng, et al. "Design, synthesis and phenotypic evaluation of N-biaryl amides for IL-17A suppression" .MEDCHEMCOMM 7,12(2016):2344-2348.

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