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Chemical Diversity in the G Protein-Coupled Receptor Superfamily 期刊论文 WOS高被引论文

编号：

56191f63-530e-419d-8026-caa0eb26f6fd
作者：

Vass, Marton^[1] Kooistra, Albert J.^[1] Yang, Dehua^[2,3] Stevens, Raymond C.^[4,5,6] Wang, MingWei^[2,3,5,7,8] de Graaf, Chris^[1]
语种：

English
期刊：

TRENDS IN PHARMACOLOGICAL SCIENCES ISSN：0165-6147 2018 年 39 卷 5 期 (494 - 512) ; MAY
收录：
摘要：

G protein-coupled receptors (GPCRs) are the largest family of cell signaling transmembrane proteins that can be modulated by a plethora of chemical compounds. Systematic cheminformatics analysis of structurally and pharma-cologically characterized GPCR ligands shows that cocrystallized GPCR ligands cover a significant part of chemical ligand space, despite their limited number. Many GPCR ligands and substructures interact with multiple receptors, providing a basis for polypharmacological ligand design. Experimentally determined GPCR structures represent a variety of binding sites and receptorligand interactions that can be translated to chemically similar ligands for which structural data are lacking. This integration of structural, pharmacological, and chemical information on GPCR-ligand interactions enables the extension of the structural GPCR-ligand interactome and the structure-based design of novel modulators of GPCR function.
推荐引用方式
GB/T 7714：

Vass Marton,Kooistra Albert J.,Yang Dehua, et al. Chemical Diversity in the G Protein-Coupled Receptor Superfamily [J].TRENDS IN PHARMACOLOGICAL SCIENCES,2018,39(5):494-512.
APA：

Vass Marton,Kooistra Albert J.,Yang Dehua,Stevens Raymond C.,&de Graaf Chris.(2018).Chemical Diversity in the G Protein-Coupled Receptor Superfamily .TRENDS IN PHARMACOLOGICAL SCIENCES,39(5):494-512.
MLA：

Vass Marton, et al. "Chemical Diversity in the G Protein-Coupled Receptor Superfamily" .TRENDS IN PHARMACOLOGICAL SCIENCES 39,5(2018):494-512.

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